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Redox proteomics analysis of head and neck cancer cell model of radiation resistance

ABSTRACT: Quantitative redox proteomics analysis was performed using the SCC-61/rSCC-61 matched model system of radiation resistance in human head and neck squamous cell carcinoma.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Tongue Squamous Epithelium

DISEASE(S): Head And Neck Squamous Cell Carcinoma

SUBMITTER: Jingyun Lee

LAB HEAD: Cristina M. Furdui

PROVIDER: PXD029053 | Pride | 2023-03-10

REPOSITORIES: Pride

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Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSM<sup>RO</sup>.

Ji Zhiwei Z Moore Jade J Devarie-Baez Nelmi O NO Lewis Joshua J Wu Hanzhi H Shukla Kirtikar K Lopez Elsa I Silva EIS Vitvitsky Victor V Key Chia-Chi Chuang CC Porosnicu Mercedes M Kemp Melissa L ML Banerjee Ruma R Parks John S JS Tsang Allen W AW Zhou Xiaobo X Furdui Cristina M CM

Frontiers in oncology 20230104

Redox metabolism is increasingly investigated in cancer as driving regulator of tumor progression, response to therapies and long-term patients' quality of life. Well-established cancer therapies, such as radiotherapy, either directly impact redox metabolism or have redox-dependent mechanisms of action defining their clinical efficacy. However, the ability to integrate redox information across signaling and metabolic networks to facilitate discovery and broader investigation of redox-regulated p ...[more]

PMID: 36686772

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