Transglutaminase 3 crosslinks MUC2 and stabilizes the colonic mucus layer

ABSTRACT: Mucus/MUC2 from TGM3-deficient mice is less cross-linked with isopeptide-bond cross-links compared to Mucus/MUC2 from WT mice. This results in protease-labile MUC2-molecules that become degraded in the colonic lumen

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

SUBMITTER: Christian Recktenwald  

LAB HEAD: Gunnar Claes Hansson

PROVIDER: PXD029071 | Pride | 2022-02-09

REPOSITORIES: Pride