Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cerebellum, Brain
SUBMITTER: Samuel Rivero-Hinojosa
LAB HEAD: Brian R Rood
PROVIDER: PXD029082 | Pride | 2021-11-02
REPOSITORIES: Pride
Nature communications 20211118 1
Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. Here we develop a proteogenomic approach combining tumor DNA/RNA sequencing and mass spectrometry proteomics to identify tumor-restricted (neoantigen) peptides arising from multiple genomic aberrations to generate a highly target-specific, autologous, personalized T cell immunotherapy. Our data indicate that aberrant splice junctions are the primary source of neoantigens in me ...[more]