Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive
ORGANISM(S): Bacteria Vibrio Campbellii (strain Atcc Baa-1116 / Bb120)
SUBMITTER: Angela Weigert Muñoz
LAB HEAD: Stephan Axel Sieber
PROVIDER: PXD029119 | Pride | 2022-04-04
REPOSITORIES: Pride
Weigert Muñoz Angela A Hoyer Elisabeth E Schumacher Kilian K Grognot Marianne M Taute Katja M KM Hacker Stephan M SM Sieber Stephan A SA Jung Kirsten K
Proceedings of the National Academy of Sciences of the United States of America 20220301 10
SignificanceHost-emitted stress hormones significantly influence the growth and behavior of various bacterial species; however, their cellular targets have so far remained elusive. Here, we used customized probes and quantitative proteomics to identify the target of epinephrine and the α-adrenoceptor agonist phenylephrine in live cells of the aquatic pathogen <i>Vibrio campbellii</i>. Consequently, we have discovered the coupling protein CheW, which is in the center of the chemotaxis signaling n ...[more]