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AC016745.3 RNA pulldown mass spectrometry data

ABSTRACT: In order to find the protein specifically bound by lncRNA-AC016745.3, we identified it through RNA pulldown combined with Protein Mass Spectrometry

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Field, Prostate Cancer Cell Line

DISEASE(S): Prostate Cancer

SUBMITTER: Yali Lu

LAB HEAD: Yao Li

PROVIDER: PXD029141 | Pride | 2022-02-15

REPOSITORIES: Pride

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AC016745.3 Regulates the Transcription of AR Target Genes by Antagonizing NONO.

Lu Yali Y Wan Xuechao X Huang Wenhua W Zhang Lu L Luo Jun J Li Dujian D Huang Yan Y Li Yao Y Xu Yaoting Y

Life (Basel, Switzerland) 20211109 11

The androgen receptor (AR) and its related signaling pathways play an important role in the development of prostate cancer (PCa). Long non-coding RNAs (lncRNAs) are involved in the regulation of tumorigenesis and development, but their specific mechanism of action remains unclear. This study examines the function and mechanisms of action of lncRNA AC016745.3 in the development of PCa. It shows that dihydrotestosterone (DHT) results in the AR-dependent suppression of AC016745.3 expr ...[more]

PMID: 34833084

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