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Interactome analysis of human phospholipase D and phosphatidic acid-associated protein network

ABSTRACT: Using a systematic proteomic approach, we define the protein-protein interaction network for PLD superfamily and phosphatidic acid in human cells and reveal diverse cellular signaling events involved for this key protein family and lipid.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Rebecca Vargas

LAB HEAD: Wenqi Wang

PROVIDER: PXD029183 | Pride | 2022-01-16

REPOSITORIES: Pride

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Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

Kattan Rebecca Elizabeth RE Han Han H Seo Gayoung G Yang Bing B Lin Yongqi Y Dotson Max M Pham Stephanie S Menely Yahya Y Wang Wenqi W

Molecular & cellular proteomics : MCP 20220108 2

Mammalian phospholipase D (PLD) enzyme family consists of six members. Among them, PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic activities. Deregulation of the PLD-PA lipid signaling has been associated with various human diseases including cancer. However, a comprehensive analysis of the regulators and effectors for this crucial lipid metabolic pathway has not been fully achieved. Using a proteomic approach, we defined the protein interaction network for ...[more]

PMID: 35007762

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