Characterization of AR interactome in prostate cancer cells after MC3324 treatment
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Prostate Cancer Cell Line
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: 
Tommaso De Marchi
LAB HEAD: Lucia Altucci
PROVIDER: PXD029249 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics.
Chianese Ugo U Papulino Chiara C Passaro Eugenia E Evers Tom Mj TM Babaei Mehrad M Toraldo Antonella A De Marchi Tommaso T Niméus Emma E Carafa Vincenzo V Nicoletti Maria Maddalena MM Del Gaudio Nunzio N Iaccarino Nunzia N Randazzo Antonio A Rotili Dante D Mai Antonello A Cappabianca Salvatore S Mashaghi Alireza A Ciardiello Fortunato F Altucci Lucia L Benedetti Rosaria R
Molecular metabolism 20220806
<h4>Objective</h4>Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in early and advanced PCa. Although direct AR signaling inhibitors exist, AR expression and function can also be epigenetically regulated. Specifically, lysine (K)-specific demethylases (KDMs), whi ...[more]
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2016-03-08 | E-GEOD-72483 | biostudies-arrayexpress
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Project description:This study aimed to further our understanding of the role that hypermethylatioted in cancer 1 (HIC1) plays in prostate cancer (PCa) development. Microarrays were searched for some genes that had correlated expression with HIC1 mRNA. Our data showed that HIC1 promoter hypermethylation was presented in cell lines, tissues and plasma of PCa patients. According to fold-change screening between restoring expression of HIC1 and its respective control cells, both up-regulated and down-regulated genes were commonly observed in PC3 and C4-2B cells. The restoring expression HIC1 in PCa lines were respectively noted as PC3-HIC1 and C4-2B-HIC1 cells, and the respective controls were noted as C4-2B-GFP and PC3-GFP cells.
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