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Impact of hormone-sensitive lipase depletion on adipocyte secretome

ABSTRACT: Hormone-sensitive lipase (HSL) is an enzyme involved in the breakdown of triacylglycerols into fatty acids, a catabolic pathway called lipolysis. Out of all mammalian cells, adipocytes express the highest levels of HSL. To explore the roles of HSL beyond adipocyte lipolysis, we performed transcriptional profiling in a human adipocyte model with siRNA-mediated depletion of HSL We observed that expression of genes involved in extracellular matrix remodeling were reduced. The project aimed at determining whether changes in mRNA levels translated into changes in secreted protein levels.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adipose-derived Stromal Cell, Stem Cell

SUBMITTER: Karima Chaoui

LAB HEAD: Odile Schiltz

PROVIDER: PXD029261 | Pride | 2026-01-30

REPOSITORIES: Pride

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	QEKAC160901_17.raw	Raw
	QEKAC160901_19.raw	Raw
	QEKAC160901_21.raw	Raw
	QEKAC160901_24.raw	Raw
	QEKAC160901_26.raw	Raw

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