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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products

ABSTRACT: The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.

INSTRUMENT(S):

ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2

SUBMITTER: Kyusik Kim

LAB HEAD: Hani Zaher

PROVIDER: PXD029291 | Pride | 2022-08-18

REPOSITORIES: Pride

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			Action	DRS
	20220120_Zaher_2045_OB_01_GFP.raw	Raw
	20220120_Zaher_2045_OB_02_11.raw	Raw
	20220120_Zaher_2045_OB_03_12.raw	Raw
	20220120_Zaher_2045_OB_04_13.raw	Raw
	20220121_Zaher_2045_OB_05_21.raw	Raw

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