Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Culture
SUBMITTER: Gerard Llimos Aubach
LAB HEAD: Bart Deplancke
PROVIDER: PXD029313 | Pride | 2022-04-21
REPOSITORIES: Pride
Llimos Gerard G Gardeux Vincent V Koch Ute U Kribelbauer Judith F JF Hafner Antonina A Alpern Daniel D Pezoldt Joern J Litovchenko Maria M Russeil Julie J Dainese Riccardo R Moia Riccardo R Mahmoud Abdurraouf Mokhtar AM Rossi Davide D Gaidano Gianluca G Plass Christoph C Lutsik Pavlo P Gerhauser Clarissa C Waszak Sebastian M SM Boettiger Alistair A Radtke Freddy F Deplancke Bart B
Nature communications 20220419 1
Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a conceptual framework of how regulatory variation might shape complex traits. To better understand the molecular mechanisms underlying VCM formation, here, we mechanistically dissect a VCM-modulating noncoding variant that is associated with reduced chronic lymphocytic ...[more]