Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Uterine Endometrial Cancer Cell, Uterine Leiomyoma Cell
DISEASE(S): Endometrial Cancer,Uterine Benign Neoplasm,Uterine Fibroid
SUBMITTER: Brian Hood
LAB HEAD: Nicholas W. Bateman, PhD
PROVIDER: PXD029323 | Pride | 2022-02-16
REPOSITORIES: Pride
iScience 20211223 1
Characterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with disease pathogenesis. Nonsynonymous single-nucleotide polymorphisms encoding missense substitutions within tryptic peptides exhibiting high allele frequencies in European, African, and East Asian populations, termed peptide ancestry informative markers (pAIMs), were prioritized from 1000 genomes. <i>In silico</i> analysis identified that as few ...[more]