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Proteomic analyses of human entorhinal cortex in Alzheimer's disease

ABSTRACT: This project aims to characterize the proteomic profile of human entorhinal cortex regarding Alzheimer's disease by SWATH-MS technique.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Daniel Saiz-Sanchez

LAB HEAD: Daniel Saiz-Sanchez

PROVIDER: PXD029359 | Pride | 2023-06-20

REPOSITORIES: Pride

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Publications

Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer-specific assessment and proteomic analysis.

Astillero-Lopez Veronica V Gonzalez-Rodriguez Melania M Villar-Conde Sandra S Flores-Cuadrado Alicia A Martinez-Marcos Alino A Ubeda-Banon Isabel I Saiz-Sanchez Daniel D

Alzheimer's & dementia : the journal of the Alzheimer's Association 20220209 12

<h4>Introduction</h4>The entorhinal cortex is among the earliest areas involved in Alzheimer's disease. Volume reduction and neural loss in this area have been widely reported. Human entorhinal cortex atrophy is, in part, due to neural loss, but microglial and/or astroglial involvement in the different layers remains unclear. Additionally, -omic approaches in the human entorhinal cortex are scarce.<h4>Methods</h4>Herein, stereological layer-specific and proteomic analyses were carried out in the ...[more]

PMID: 35142030

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