Proteomic and Glycoproteomic Analyses of Fucosylated Glycoproteins in Head and Neck Cancer Cell Lines
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: 
Kevin Chandler
LAB HEAD: Kevin Brown Chandler
PROVIDER: PXD029420 | Pride | 2022-02-14
REPOSITORIES: Pride
Publications
Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.
Montesino Brittany B Steenackers Agata A Lozano Juan M JM Young Geoffrey D GD Hu Nan N Sackstein Robert R Chandler Kevin Brown KB
Glycobiology 20220401 5
Head and neck cancer is the seventh most common cancer in the world, and most cases manifest as head and neck squamous cell carcinoma. Despite the prominent role of fucosylated carbohydrate antigens in tumor cell adhesion and metastasis, little is known about the functional role of fucose-modified glycoproteins in head and neck cancer pathobiology. Inactivating polymorphisms of the fut2 gene, encoding for the α1,2-fucosyltransferase FUT2, are associated with an increased incidence of head and ne ...[more]
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