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Role of EVs in inflammation propagation and oxidative stress during vascular calcification

ABSTRACT: Role of EVs in inflammation propagation and oxidative stress during vascular calcification

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Macrophage

SUBMITTER: Vincent Jung

LAB HEAD: Chiara Guerrera

PROVIDER: PXD029441 | Pride | 2022-05-19

REPOSITORIES: Pride

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Extracellular Vesicles From LPS-Treated Macrophages Aggravate Smooth Muscle Cell Calcification by Propagating Inflammation and Oxidative Stress.

Yaker Linda L Tebani Abdellah A Lesueur Céline C Dias Chloé C Jung Vincent V Bekri Soumeya S Guerrera Ida Chiara IC Kamel Saïd S Ausseil Jérôme J Boullier Agnès A

Frontiers in cell and developmental biology 20220309

<b>Background:</b> Vascular calcification (VC) is a cardiovascular complication associated with a high mortality rate among patients with diseases such as atherosclerosis and chronic kidney disease. During VC, vascular smooth muscle cells (VSMCs) undergo an osteogenic switch and secrete a heterogeneous population of extracellular vesicles (EVs). Recent studies have shown involvement of EVs in the inflammation and oxidative stress observed in VC. We aimed to decipher the role and mechanism of act ...[more]

PMID: 35356285

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