Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Oligodendrocyte
DISEASE(S): Neurodegenerative Disease
SUBMITTER: Olaf Jahn
LAB HEAD: Prof. Dr. Olaf Jahn
PROVIDER: PXD029443 | Pride | 2022-04-04
REPOSITORIES: Pride
Buscham Tobias J TJ Eichel-Vogel Maria A MA Steyer Anna M AM Jahn Olaf O Strenzke Nicola N Dardawal Rakshit R Memhave Tor R TR Siems Sophie B SB Müller Christina C Meschkat Martin M Sun Ting T Ruhwedel Torben T Möbius Wiebke W Krämer-Albers Eva-Maria EM Boretius Susann S Nave Klaus-Armin KA Werner Hauke B HB
eLife 20220311
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown. Here, we find that expression of the tetraspan-transmembrane protein CMTM5 (chemokine-like factor-like MARVEL-transmembrane domain containing protein 5) is highly enriched in oligodendrocytes and central nervous system (CNS) myelin. Genetic disruption of the <i>Cmtm5</i> gene in oligodendrocytes ...[more]