Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Epithelium Of Pancreatic Duct, Pancreatic Stellate Cell
DISEASE(S): Pancreatic Ductal Adenocarcinoma
SUBMITTER: Yi-Ing Chen
LAB HEAD: Wen-Hwa Lee
PROVIDER: PXD029467 | Pride | 2022-06-09
REPOSITORIES: Pride
Chen Yi-Ing YI Chang Chin-Chun CC Hsu Min-Fen MF Jeng Yung-Ming YM Tien Yu-Wen YW Chang Ming-Chu MC Chang Yu-Ting YT Hu Chun-Mei CM Lee Wen-Hwa WH
Nature communications 20220526 1
Tumor cells with diverse phenotypes and biological behaviors are influenced by stromal cells through secretory factors or direct cell-cell contact. Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia with fibroblasts as the major cell type. In the present study, we observe enrichment of myofibroblasts in a juxta-tumoral position with tumor cells undergoing epithelial-mesenchymal transition (EMT) that facilitates invasion and correlates with a worse clinical prognosi ...[more]