Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Evangelia Papachristou
LAB HEAD: Sakari Vanharanta
PROVIDER: PXD029522 | Pride | 2022-03-14
REPOSITORIES: Pride
Patel Saroor A SA Hirosue Shoko S Rodrigues Paulo P Vojtasova Erika E Richardson Emma K EK Ge Jianfeng J Syafruddin Saiful E SE Speed Alyson A Papachristou Evangelia K EK Baker David D Clarke David D Purvis Stephenie S Wesolowski Ludovic L Dyas Anna A Castillon Leticia L Caraffini Veronica V Bihary Dóra D Yong Cissy C Harrison David J DJ Stewart Grant D GD Machiela Mitchell J MJ Purdue Mark P MP Chanock Stephen J SJ Warren Anne Y AY Samarajiwa Shamith A SA Carroll Jason S JS Vanharanta Sakari S
Nature 20220608 7916
Large-scale human genetic data<sup>1-3</sup> have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrate that the lineage transcription factor paired box 8 (PAX8) is required for oncogenic signalling by two common genetic alterations that cause clear cell renal cell carcinoma (ccRCC) in humans: the germline variant rs7948643 at 11q13.3 and ...[more]