Proteomic characterization of Prostate cancer cell lines
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell Of Prostate, Cell Culture
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: 
Tommaso De Marchi
LAB HEAD: Lucia Altucci
PROVIDER: PXD029525 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics.
Chianese Ugo U Papulino Chiara C Passaro Eugenia E Evers Tom Mj TM Babaei Mehrad M Toraldo Antonella A De Marchi Tommaso T Niméus Emma E Carafa Vincenzo V Nicoletti Maria Maddalena MM Del Gaudio Nunzio N Iaccarino Nunzia N Randazzo Antonio A Rotili Dante D Mai Antonello A Cappabianca Salvatore S Mashaghi Alireza A Ciardiello Fortunato F Altucci Lucia L Benedetti Rosaria R
Molecular metabolism 20220806
<h4>Objective</h4>Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in early and advanced PCa. Although direct AR signaling inhibitors exist, AR expression and function can also be epigenetically regulated. Specifically, lysine (K)-specific demethylases (KDMs), whi ...[more]
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