Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically ill COVID-19 patients

ABSTRACT: In this study, we aim to evaluate the relation between COVID-19 and bacterial secondary superinfections. We assessed the functional responses of neutrophils and monocytes isolated from acute and recovery COVID-19 patients upon bacterial infection using Flow-cytometry and proteomics based assays. Both neutrophils and monocytes showed impared intracellular microbicidal capacity along with a decreased functional response. Determination of plasma cytokines levels showed a significant association of certain cytokines towards secondary bacterial infection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Covid-19

SUBMITTER: Alejandro Gomez Mejia  

LAB HEAD: Annelies S. Zinkernagel

PROVIDER: PXD029547 | Pride | 2021-12-10

REPOSITORIES: Pride