Computational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Aorta
SUBMITTER: 
Sasha Singh
LAB HEAD: Elena Aikawa
PROVIDER: PXD029963 | Pride | 2022-02-17
REPOSITORIES: Pride
Publications
Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification.
Tanaka Takeshi T Asano Takaharu T Okui Takehito T Kuraoka Shiori S Singh Sasha A SA Aikawa Masanori M Aikawa Elena E
Frontiers in cardiovascular medicine 20220120
Vascular calcification is a cardiovascular disorder with no therapeutic options. We recently reported that <i>o</i>-octanoyltransferase (CROT) suppression can inhibit vascular calcification <i>in vivo</i> and <i>in vitro</i> through amelioration of mitochondrial function and fatty acid metabolism. Inhibiting calcification with a small molecule compound targeting CROT-associated mechanisms will be a promising non-invasive treatment of vascular calcification. Here we used a computational approach ...[more]
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