Quantitative label-free proteomic comparison of the omadacycline-induced E. faecium isolates vs initial separation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Enterococcus Faecalis (streptococcus Faecalis)
SUBMITTER: 
Yuxi Zhao
LAB HEAD: Yuxi Zhao
PROVIDER: PXD029978 | Pride | 2022-02-17
REPOSITORIES: Pride
Publications
The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis.
Wen Zewen Z Zhao Yuxi Y Gong Zhengyang Z Tang Yuanyuan Y Xiong Yanpeng Y Chen Junwen J Chen Chengchun C Zhang Yufang Y Liu Shanghong S Zheng Jinxin J Li Duoyun D Deng Qiwen Q Yu Zhijian Z
Microbiology spectrum 20220112 1
With the increasing reports of community-acquired and nosocomial infection caused by multidrug-resistant Gram-positive pathogens, there is an urgent need to develop new antimicrobial agents with novel antibacterial mechanisms. Here, we investigated the antibacterial activity of the natural product ginkgolic acid (GA) (15:1), derived from Ginkgo biloba, and its potential mode of action against the Gram-positive bacteria Enterococcus faecalis and Staphylococcus aureus. The MIC values of GA (15:1) ...[more]
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