Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuroendocrine Tumor Cell, Stroma, Small Intestine Glandular Cell
DISEASE(S): Small Intestine Neuroendocrine Neoplasm
SUBMITTER: Christoph Stingl
LAB HEAD: Theo Luider
PROVIDER: PXD029979 | Pride | 2022-05-20
REPOSITORIES: Pride
Blažević Anela A Iyer Anand M AM van Velthuysen Marie-Louise F MF Hofland Johannes J van Koestveld Peter M PM Franssen Gaston J H GJH Feelders Richard A RA Zajec Marina M Luider Theo M TM de Herder Wouter W WW Hofland Leo J LJ
Endocrine connections 20220429 4
<h4>Background</h4>Increased levels of serotonin secretion are associated with mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs). However, the profibrotic potential of serotonin differs between patients, and in this study, we aimed to gain an understanding of the mechanisms underlying this variability. To this end, we analyzed the proteins involved in tryptophan metabolism in SI-NETs.<h4>Methods</h4>Proteomes of tumor and stroma from primary SI-NETs and paired mesenter ...[more]