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LFQ of mouse brain in ischemic stroke

ABSTRACT: Ischemic disorders are the leading cause of death worldwide. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are part of the Raf/MEK/ERK1/2 cascade and are thought to affect the outcome of ischemic stroke. However, it is under debate whether activation or inhibition of ERK1/2 is beneficial. Therefore, this study aimed to investigate the impact of ERK1/2 after cerebral ischemia using transgenic mice with ubiquitous overexpression of ERK2 or of the Raf kinase inhibitor protein (RKIP), an inhibitor of the ERK1/2 signaling cascade.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yvonne Reinders

LAB HEAD: Kristina Lorenz

PROVIDER: PXD030067 | Pride | 2022-02-17

REPOSITORIES: Pride

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ERK1/2 Activity Is Critical for the Outcome of Ischemic Stroke.

Schanbacher Constanze C Bieber Michael M Reinders Yvonne Y Cherpokova Deya D Teichert Christina C Nieswandt Bernhard B Sickmann Albert A Kleinschnitz Christoph C Langhauser Friederike F Lorenz Kristina K

International journal of molecular sciences 20220109 2

Ischemic disorders are the leading cause of death worldwide. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) are thought to affect the outcome of ischemic stroke. However, it is under debate whether activation or inhibition of ERK1/2 is beneficial. In this study, we report that the ubiquitous overexpression of wild-type ERK2 in mice (ERK2<sup>wt</sup>) is detrimental after transient occlusion of the middle cerebral artery (tMCAO), as it led to a massive increase in infarct volume and ...[more]

PMID: 35054890

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