Cubilin is a Novel Target Antigen in Anti-Brush Border Antibody Disease

ABSTRACT: Autoimmune diseases that affect the kidney proximal tubule (PT) cause proteinuria and are implicated in the pathogenesis of kidney failure. Previous evidence demonstrated that circulating anti-brush border antibodies (ABBA) target megalin (LRP2) but whether other components of the PT drive autoimmunity was unknown. Here we investigate a patient with LRP2-negative ABBA disease, and applied immunoprecipitation, mass spectrometry, and confocal imaging to identify cubilin as a novel antigen associated with the autoimmune disorder.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Proximal Tubule, Kidney

SUBMITTER: Aaron Storey  

LAB HEAD: Christopher Larsen

PROVIDER: PXD030159 | Pride | 2023-04-06

REPOSITORIES: Pride