Temporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease

ABSTRACT: Mouse models of Alzheimer’s Disease (AD), which show progression through various AD stages reflective of human pathology, like 5XFAD, are well established tools for uncovering novel AD related pathways. In addition, they permit temporal examination of the intermingling of AD related pathways and can be used to potentially dissect initiating and propagating events in AD, which are critical for developing biomarkers or designing interventions in early stages of the disease. The present research offers a robust and exhaustive tandem MS examination of a familial AD mice model with a design including variables of: time (three, six, and nine months), genetic background (5XFAD vs. WT), and sex (equal males and females).

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hippocampus

SUBMITTER: Filipa Blasco Tavares Pereira Lopes  

LAB HEAD: Mark R. Chance

PROVIDER: PXD030161 | Pride | 2022-09-16

REPOSITORIES: pride