Dataset Information
Proteomics of KRAS mutated and non-transformed pancreas cells treated with ethanol
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell Of Pancreas
DISEASE(S): Pancreatic Ductal Adenocarcinoma
SUBMITTER: 
Emalie Clement
LAB HEAD: Nicholas T. Woods
PROVIDER: PXD030180 | Pride | 2022-05-19
REPOSITORIES: Pride
Publications
Combined Alcohol Exposure and KRAS Mutation in Human Pancreatic Ductal Epithelial Cells Induces Proliferation and Alters Subtype Signatures Determined by Multi-Omics Analysis.
Cancers 20220413 8
Pancreatic Ductal adenocarcinoma (PDAC) is an aggressive cancer commonly exhibiting KRAS-activating mutations. Alcohol contributes to the risk of developing PDAC in humans, and murine models have shown alcohol consumption in the context of KRAS mutation in the pancreas promotes the development of PDAC. The molecular signatures in pancreas cells altered by alcohol exposure in the context of mutant KRAS could identify pathways related to the etiology of PDAC. In this study, we evaluated the combin ...[more]
