Dataset Information
TMT analysis of tissue proteomics in bevacizumab-resistant xenograft tumor tissuein nude mice
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colon
DISEASE(S): Colon Cancer
SUBMITTER: 
Yuning Lin
LAB HEAD: Dongmei Zhang
PROVIDER: PXD030202 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.
The Journal of clinical investigation 20221003 19
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel co-option have mainly focused on "hijacker" tumor cells, whereas the function of the "hijackee" sinusoidal blood vessels has not been explored. Here, we found that the occurrence of vessel co-option in bevacizumab-resistant CRCLM xenografts was associated with increased expression of fibroblast activation protein α (FAPα) in t ...[more]
