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Mass Spectrometry analysis of human matched Anterior and Posterior lobes of Pituitary

ABSTRACT: This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes. Anterior Lobe n=5 Posterior Lobe n=5 A441 PT441 A442 PT442 A457 PT457 A459 PT459 A460 PT460

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Pituitary Gland

DISEASE(S): Disease Free

SUBMITTER: Arghya Banerjee

LAB HEAD: Prof. Sanjeeva Srivastava

PROVIDER: PXD030235 | Pride | 2022-12-07

REPOSITORIES: Pride

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The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland.

Banerjee Arghya A Biswas Deepatarup D Barpanda Abhilash A Halder Ankit A Sibal Shamira S Kattimani Rohit R Shah Abhidha A Mahadevan Anita A Goel Atul A Srivastava Sanjeeva S

Molecular & cellular proteomics : MCP 20221205 1

To date, very few mass spectrometry (MS)-based proteomics studies are available on the anterior and posterior lobes of the pituitary. In the past, MS-based investigations have focused exclusively on the whole pituitary gland or anterior pituitary lobe. In this study, for the first time, we performed a deep MS-based analysis of five anterior and five posterior matched lobes to build the first lobe-specific pituitary proteome map, which documented 4090 proteins with isoforms, mostly mapped into ch ...[more]

PMID: 36470533

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