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Hypoxia-Induced Regulation of the Proteome in Multiple Myeloma Cell Lines

ABSTRACT: Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1-6% O2), known as hypoxia. For MM cells, hypoxia is a physiologic feature that has been described to promote an aggressive phenotype and to confer drug resistance. However, studies on hypoxia are scarce and show little conformity. Here, we analyzed the global proteome in MM cells and the stromal cell line HS-5 to reveal hypoxia-dependent regulation of proteins.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Plasma Cell

DISEASE(S): Multiple Myeloma

SUBMITTER: Frank Schnütgen

LAB HEAD: Hubert Serve

PROVIDER: PXD030239 | Pride | 2022-02-16

REPOSITORIES: Pride

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Publications

Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene.

Clees Ada-Sophia AS Stolp Verena V Häupl Björn B Fuhrmann Dominik C DC Wempe Frank F Seibert Marcel M Weber Sarah S Banning Antje A Tikkanen Ritva R Williams Richard R Brüne Bernhard B Serve Hubert H Schnütgen Frank F von Metzler Ivana I Kurrle Nina N

Cells 20220115 2

Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1-6% O<sub>2</sub>), known as hypoxia. For MM cells, hypoxia is a physiologic feature that has been described to promote an aggressive phenotype and to confer drug resistance. However, studies on hypoxia are scarce and show little conformity. Here, we analyzed the mRNA exp ...[more]

PMID: 35053409

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