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Pan-cancer proteomic map of 949 human cell lines (ProCan-DepMapSanger)

ABSTRACT: This pan-cancer cell line proteomic atlas comprises proteomic data acquired by data independent acquisition (specifically, SWATH) mass spectrometry for 949 cancer cell lines. Cell lines were processed in technical triplicate, with duplicates acquired on different mass spectrometers, alongside HEK293T cell line control samples processed across the experimental period. For further details, refer to the publication that accompanies this data deposition.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Rebecca Poulos

LAB HEAD: Qing Zhong

PROVIDER: PXD030304 | Pride | 2022-07-13

REPOSITORIES: Pride

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Pan-cancer proteomic map of 949 human cell lines.

Gonçalves Emanuel E Poulos Rebecca C RC Cai Zhaoxiang Z Barthorpe Syd S Manda Srikanth S SS Lucas Natasha N Beck Alexandra A Bucio-Noble Daniel D Dausmann Michael M Hall Caitlin C Hecker Michael M Koh Jennifer J Lightfoot Howard H Mahboob Sadia S Mali Iman I Morris James J Richardson Laura L Seneviratne Akila J AJ Shepherd Rebecca R Sykes Erin E Thomas Frances F Valentini Sara S Williams Steven G SG Wu Yangxiu Y Xavier Dylan D MacKenzie Karen L KL Hains Peter G PG Tully Brett B Robinson Phillip J PJ Zhong Qing Q Garnett Mathew J MJ Reddel Roger R RR

Cancer cell 20220714 8

The proteome provides unique insights into disease biology beyond the genome and transcriptome. A lack of large proteomic datasets has restricted the identification of new cancer biomarkers. Here, proteomes of 949 cancer cell lines across 28 tissue types are analyzed by mass spectrometry. Deploying a workflow to quantify 8,498 proteins, these data capture evidence of cell-type and post-transcriptional modifications. Integrating multi-omics, drug response, and CRISPR-Cas9 gene essentiality screen ...[more]

PMID: 35839778

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