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The effect of metformin on the neural differentiation of gingival mesenchymal stem cells in three-dimensional culture

ABSTRACT: Proteomics was used to explore the effect of metformin on the neural differentiation of gingival mesenchymal stem cells in three-dimensional culture.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell, Cell Culture

SUBMITTER: Tong Lei

LAB HEAD: Hongwu Du

PROVIDER: PXD030306 | Pride | 2022-04-04

REPOSITORIES: Pride

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Chitosan Hydrogel Supplemented with Metformin Promotes Neuron-like Cell Differentiation of Gingival Mesenchymal Stem Cells.

Cai Shanglin S Lei Tong T Bi Wangyu W Sun Shutao S Deng Shiwen S Zhang Xiaoshuang X Yang Yanjie Y Xiao Zhuangzhuang Z Du Hongwu H

International journal of molecular sciences 20220318 6

Human gingival mesenchymal stem cells (GMSCs) are derived from migratory neural crest stem cells and have the potential to differentiate into neurons. Metformin can inhibit stem-cell aging and promotes the regeneration and development of neurons. In this study, we investigated the potential of metformin as an enhancer on neuronal differentiation of GMSCs in the growth environment of chitosan hydrogel. The crosslinked chitosan/β-glycerophosphate hydrogel can form a perforated microporous structur ...[more]

PMID: 35328696

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