Proteomics

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Rabbit liver tissue infected with rabbit hemorrhagic disease virus (RHDV) LC-MS

ABSTRACT: The rabbit hemorrhagic disease virus (RHDV) represents the causative agent of a highly contagious disease in rabbits that is often associated with high mortality. Because of the lack of a suitable cell culture system for RHDV, the pathogenic mechanism and replication of RHDV remains unclear. In order to analyze the pathogenic mechanism of RHDV to rabbits, we used New Zealand white rabbits infected with RHDV, collected liver tissues 32 hours after infection, and used TMT labeling for LC-MS analysis. Subsequently, it was compared and analyzed with the protein data of the liver tissue of the uninfected rabbits. Perform bioinformatics analysis on significantly different proteins. Finally, comprehensively analyze the influence of RHDV on host protein and pathway expression levels. This study provides clues to clarify the pathogenic mechanism of RHDV in rabbits.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Oryctolagus Cuniculus (rabbit)

TISSUE(S): Liver

SUBMITTER: Jie Zhu  

LAB HEAD: Guangqing Liu

PROVIDER: PXD030318 | Pride | 2022-05-19

REPOSITORIES: Pride

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Publications

Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene.

Yang Hongzao H   Zhu Jie J   Guo Hongyuan H   Tang Aoxing A   Chen Shaoyu S   Zhang Da D   Yuan Ligang L   Liu Guangqing G  

BMC veterinary research 20220510 1

<h4>Background</h4>The mammalian genome encodes millions of proteins. Although many proteins have been discovered and identified, a large part of proteins encoded by genes are yet to be discovered or fully characterized. In the present study, we successfully identified a host protein C11orf96 that was significantly upregulated after viral infection.<h4>Results</h4>First, we successfully cloned the coding sequence (CDS) region of the cat, human, and mouse C11orf96 gene. The CDS region of the C11o  ...[more]

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