PFN4 is required for acrosome biogenesis by regulating autophagy through PI3K/AKT/mTOR pathway

ABSTRACT: We generated Pfn4 knockout mice and showed that male mice are infertile and acrosome biogenesis is impaired from first phase of Development (Golgi-phase). Autophagy participates in acrosome formation and LC-MS data showed proteins related to autophagy, PI3K/AKT signaling and mTOR are enriched in PFN4-/- male mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

DISEASE(S): Male Infertility

SUBMITTER: Marc Sylvester  

LAB HEAD: Hubert Schorle

PROVIDER: PXD030394 | Pride | 2022-08-15

REPOSITORIES: Pride