Proteomics

Dataset Information

0

Venous hypertensive myelopathy LC-MS/MS


ABSTRACT: A major challenge in Spinal Dural Arteriovenous Fistula (SDAVF) was its timely diagnosis, but no specific predictive biomarkers were known. In the discovery cohort (case, n=8 vs. control, n=8), we used cerebrospinal fluid (CSF) and paired plasma samples to identify differentially expressed proteins by label-free quantitative proteomics. Further bioinformatics enrichment analyses were performed to screen target proteins. Finally, it was validated by ELISA experiment in two of the new cohort (case, n=17 vs. control, n=9).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Cerebrospinal Fluid

DISEASE(S): Vascular Myelopathy

SUBMITTER: yinqing wang  

LAB HEAD: China International Neuroscience Institute

PROVIDER: PXD030479 | Pride | 2022-08-11

REPOSITORIES: Pride

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Publications

Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA.

Wang Yinqing Y   Ma Yongjie Y   Yang Chengbin C   Huang Xiahe X   Yang Kun K   Lan Fei F   Fu Jingxuan J   Song Zihao Z   Tian An A   Feng Yueshan Y   Tu Tianqi T   Li Haifeng H   Hong Tao T   Wang Yingchun Y   Zhang Hongqi H  

Journal of neuroinflammation 20220622 1


<h4>Background and purpose</h4>A major challenge in spinal dural arteriovenous fistula (SDAVF) is timely diagnosis, but no specific predictive biomarkers are known.<h4>Methods</h4>In the discovery cohort (case, n = 8 vs. control, n = 8), we used cerebrospinal fluid (CSF) and paired plasma samples to identify differentially expressed proteins by label-free quantitative proteomics. Further bioinformatics enrichment analyses were performed to screen target proteins. Finally, it was validated by ELI  ...[more]

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