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Dissection of acetylomic profiles in T cell lymphoma following histone deacetylases inhibition

ABSTRACT: The aim was to dissect molecular changes in histone and non-histone protein acetylation dynamics following the genetic or pharmacological inhibition of HDAC activity in a model of Anaplastic Large Cell Lymphoma (ALCL), a T cell non-Hodgkin lymphoma, predominantly found in children and adolescents.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): T Cell

DISEASE(S): Lymphoma

SUBMITTER: Gabriela Lochmanova

LAB HEAD: Zbynek Zdrahal

PROVIDER: PXD030503 | Pride | 2022-10-14

REPOSITORIES: Pride

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Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma.

Zrimšek Maša M Kuchaříková Hana H Draganić Kristina K Dobrovolná Pavlína P Heiss Spornberger Verena V Winkelmayer Lisa L Hassler Melanie R MR Lochmanová Gabriela G Zdráhal Zbyněk Z Egger Gerda G

Cells 20220802 15

Histone deacetylases (HDACs) target acetylated lysine residues in histone and non-histone proteins. HDACs are implicated in the regulation of genomic stability, cell cycle, cell death and differentiation and thus critically involved in tumorigenesis. Further, HDACs regulate T-cell development and HDAC inhibitors (HDACis) have been approved for clinical use in some T-cell malignancies. Still, the exact targets and mechanisms of HDAC inhibition in cancer are understudied. We isolated tumor cell li ...[more]

PMID: 35954222

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