Aggregation as a host defense mechanism

ABSTRACT: In this work, we hypothesized that the aggregation of proteins during wounding is a physiological host defense mechanism, which is triggered during pathogen invasion. Here, we demonstrate the ability of acute wound fluids (AWFs) to aggregate their protein content after exposer to bacterial endotoxins such as lipopolysaccharides (LPS). The composition of LPS-triggered aggregates clearly shows the enrichment of specific protein families, which are for example involved in the immune system, coagulation cascade, nuclear matrix, or lipid metabolism.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Wound Fluid, Wound Healing Involved In Inflammatory Response

DISEASE(S): Wounds And Injuries

SUBMITTER: Charlotte Welinder  

LAB HEAD: Jitka Petrlova

PROVIDER: PXD030521 | Pride | 2023-10-12

REPOSITORIES: Pride