Proteome / pYome of LYN deficient HS-5 stroma cells

ABSTRACT: LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effect of LYN kinase on the leukemia supportive phenotype of the bone marrow stromal cell line HS-5, we generated single cell clones of LYN deficient cells. These cells were analyzed in a Multi-Omic approach, including quantitative, label-free proteomic analysis of the Proteome / SILAC labelled analysis of the tyrosine phosphoproteome.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stromal Cell Of Bone Marrow, Cell Culture

SUBMITTER: Alexander F. vom Stein  

LAB HEAD: Prof. Michael Hallek

PROVIDER: PXD030582 | Pride | 2023-05-10

REPOSITORIES: Pride