Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stromal Cell Of Bone Marrow, Cell Culture
SUBMITTER: Alexander F. vom Stein
LAB HEAD: Prof. Michael Hallek
PROVIDER: PXD030582 | Pride | 2023-05-10
REPOSITORIES: Pride
Vom Stein Alexander F AF Rebollido-Rios Rocio R Lukas Anna A Koch Maximilian M von Lom Anton A Reinartz Sebastian S Bachurski Daniel D Rose France F Bozek Katarzyna K Abdallah Ali T AT Kohlhas Viktoria V Saggau Julia J Zölzer Rebekka R Zhao Yue Y Bruns Christiane C Bröckelmann Paul J PJ Lohneis Philipp P Büttner Reinhard R Häupl Björn B Oellerich Thomas T Nguyen Phuong-Hien PH Hallek Michael M
Nature communications 20230310 1
Microenvironmental bystander cells are essential for the progression of chronic lymphocytic leukemia (CLL). We have discovered previously that LYN kinase promotes the formation of a microenvironmental niche for CLL. Here we provide mechanistic evidence that LYN regulates the polarization of stromal fibroblasts to support leukemic progression. LYN is overexpressed in fibroblasts of lymph nodes of CLL patients. LYN-deficient stromal cells reduce CLL growth in vivo. LYN-deficient fibroblasts show m ...[more]