Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 240
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Adult Extraosseous Osteosarcoma
SUBMITTER: Vyacheslav Akimov
LAB HEAD: Dr. Prof. Blagoy Blagoev
PROVIDER: PXD030644 | Pride | 2022-05-23
REPOSITORIES: Pride
Trulsson Fredrik F Akimov Vyacheslav V Robu Mihaela M van Overbeek Nila N Berrocal David Aureliano Pérez DAP Shah Rashmi G RG Cox Jürgen J Shah Girish M GM Blagoev Blagoy B Vertegaal Alfred C O ACO
Nature communications 20220518 1
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of the proteasome and DUBs on the global ubiquitinome, using UbiSite technology, inhibitors and mass spectrometry. We uncover large dynamic ubiquitin signalling networks with substrates and sites preferentially regulated by DUBs or by the proteasome, highlighting the role of DUBs in de ...[more]