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Breast cancer mitochondria pulldown

ABSTRACT: pull-down of protein extracted from isolated mitochondria fraction

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Henri-Baptiste Marjault

LAB HEAD: Rachel Nechushtai

PROVIDER: PXD030730 | Pride | 2022-02-22

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20210707-02-blank.raw	Raw
	20210707-06-MiNT.raw	Raw
	peptides.txt	Txt
	peptides__1_.txt	Txt

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1 - 4 of 4

Publications

A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics.

Karmi Ola O Marjault Henri-Baptiste HB Bai Fang F Roy Susmita S Sohn Yang-Sung YS Darash Yahana Merav M Morcos Faruck F Ioannidis Konstantinos K Nahmias Yaakov Y Jennings Patricia A PA Mittler Ron R Onuchic José N JN Nechushtai Rachel R

Proceedings of the National Academy of Sciences of the United States of America 20220201 7

Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET (mNT) proteins belong to the NEET protein family. This family plays a key role in mitochondrial labile iron and reactive oxygen species (ROS) homeostasis. NEET proteins contain labile [2Fe-2S] clusters which can be transferred to apo-acceptor proteins. In eukaryotes, the biogenesis of [2Fe-2S] clusters occurs within the mitochondria by the iron-sulfur cluster (ISC) system; the clusters are then transferred to [2F ...[more]

PMID: 35135884

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