Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Petra Beli
LAB HEAD: Petra Beli
PROVIDER: PXD030735 | Pride | 2022-04-25
REPOSITORIES: Pride
Molecular cell 20220308 8
A polyubiquitin chain can adopt a variety of shapes, depending on how the ubiquitin monomers are joined. However, the relevance of linkage for the signaling functions of polyubiquitin chains is often poorly understood because of our inability to control or manipulate this parameter in vivo. Here, we present a strategy for reprogramming polyubiquitin chain linkage by means of tailor-made, linkage- and substrate-selective ubiquitin ligases. Using the polyubiquitylation of the budding yeast replica ...[more]