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Data in support of Gold micro-particles for knee osteoarthritisGold micro-particles for knee osteoarthritis

ABSTRACT: This study investigated the effect of intraarticular gold micro particle implants for the treatment of pain and inflammation in KOA. The present open, exploratory, proof-of-concept study investigated whether intraarticular gold ions could act as a KOA treatment option through modulation of inflammatory mediators, pain sensitivity, and central pain mechanisms. The primary aim of this study were 1) to measure the effect on pain and function after intra-articular injection of 20 mg gold microparticles > 20 µm into the KOA joint using the patient’s synovial fluid (SF) as a carrier and 2) measure associated possible proteomic changes in the SF and serum.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Allan Stensballe

LAB HEAD: Allan Stensballe

PROVIDER: PXD030746 | Pride | 2022-12-03

REPOSITORIES: Pride

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Gold micro-particles for knee osteoarthritis.

Rasmussen Sten S Kjaer Petersen Kristian K Kristiansen Martin Kaae MK Skallerup Jakob J Aboo Christopher C Thomsen Mikkel Eggert ME Skjoldemose Emilie E Jørgensen Nia Kristine NK Stensballe Allan A Arendt-Nielsen Lars L

European journal of pain (London, England) 20220201 4

<h4>Background</h4>This exploratory study investigates if intra-articular injected gold microparticles in knee osteoarthritis (KOA) reduce immunomodulatory-based pain via proteomic changes in the synovial fluid (SF) and serum.<h4>Methods</h4>Thirty patients with moderate KOA were included. Intraarticular injections with 20 mg gold microparticles (72.000 particles, 20-40 µm in diameter) using the patient's synovial fluid (SF) as carrier were performed. Western Ontario and McMaster Universities Os ...[more]

PMID: 35076138

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