MIA PaCa-2 cells treated with Gemcitabine
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Sailee Rasam
LAB HEAD: Jun Qu
PROVIDER: PXD030861 | Pride | 2022-09-15
REPOSITORIES: Pride
Publications
Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer.
Lin Qingxiang Q Shen Shichen S Qian Zhicheng Z Rasam Sailee S SS Serratore Andrea A Jusko William J WJ Kandel Eugene S ES Qu Jun J Straubinger Robert M RM
Molecular & cellular proteomics : MCP 20220907 10
Pancreatic adenocarcinoma (PDAC) is highly refractory to treatment. Standard-of-care gemcitabine (Gem) provides only modest survival benefits, and development of Gem resistance (GemR) compromises its efficacy. Highly GemR clones of Gem-sensitive MIAPaCa-2 cells were developed to investigate the molecular mechanisms of GemR and implemented global quantitative differential proteomics analysis with a comprehensive, reproducible ion-current-based MS1 workflow to quantify ∼6000 proteins in all sample ...[more]
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