Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Vasin Dumrongprechachan
LAB HEAD: Yevgenia Kozorovitskiy
PROVIDER: PXD030864 | Pride | 2022-10-26
REPOSITORIES: Pride
Dumrongprechachan Vasin V Salisbury Ryan B RB Butler Lindsey L MacDonald Matthew L ML Kozorovitskiy Yevgenia Y
eLife 20221014
Mammalian axonal development begins in embryonic stages and continues postnatally. After birth, axonal proteomic landscape changes rapidly, coordinated by transcription, protein turnover, and post-translational modifications. Comprehensive profiling of axonal proteomes across neurodevelopment is limited, with most studies lacking cell-type and neural circuit specificity, resulting in substantial information loss. We create a Cre-dependent APEX2 reporter mouse line and map cell-type-specific prot ...[more]