Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q TRAP
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Christopher Hughes
LAB HEAD: Gregg Morin
PROVIDER: PXD030942 | Pride | 2023-06-30
REPOSITORIES: Pride
Takemon Yuka Y LeBlanc Véronique G VG Song Jungeun J Chan Susanna Y SY Lee Stephen Dongsoo SD Trinh Diane L DL Ahmad Shiekh Tanveer ST Brothers William R WR Corbett Richard D RD Gagliardi Alessia A Moradian Annie A Cairncross J Gregory JG Yip Stephen S Aparicio Samuel A J R SAJR Chan Jennifer A JA Hughes Christopher S CS Morin Gregg B GB Gorski Sharon M SM Chittaranjan Suganthi S Marra Marco A MA
Cancers 20230517 10
<i>CIC</i> encodes a transcriptional repressor and MAPK signalling effector that is inactivated by loss-of-function mutations in several cancer types, consistent with a role as a tumour suppressor. Here, we used bioinformatic, genomic, and proteomic approaches to investigate CIC's interaction networks. We observed both previously identified and novel candidate interactions between CIC and SWI/SNF complex members, as well as novel interactions between CIC and cell cycle regulators and RNA process ...[more]