Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila

ABSTRACT: Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is a central question of developmental biology, but the mechanisms controlling mitosis and differentiation are considered to be fundamentally distinct. Here we show the mitotic kinase Polo, which regulates all steps of mitosis in Drosophila, also directs cellular morphogenesis after cell cycle exit.

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

TISSUE(S): Whole Body

SUBMITTER: Shuo Yang  

LAB HEAD: Aaron Johnson

PROVIDER: PXD030953 | Pride | 2022-01-14

REPOSITORIES: Pride