Proteomics

Dataset Information

0

Fatty acid transport protein 2 interacts with ceramide synthase 2 to regulate ceramide synthesis


ABSTRACT: Dihydroceramide is generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, namely sphinganine and fatty acyl CoAs. Sphinganine is generated via the sequential activity of two integral membrane proteins located in the endoplasmic reticulum. Less is known about the source of supply of the fatty acyl CoAs, although a number of cytosolic proteins in the pathways of acyl CoA generation have been shown to modulate ceramide synthesis via direct or indirect interaction with the CerSs. We now demonstrate, by proteomic analysis of immunoprecipitated proteins, that fatty acid transporter protein 2 (FATP2) (also known as very long-chain acyl-CoA synthetase) directly interacts with CerS2 in mouse liver. Studies in cultured cells demonstrated that other members of the FATP family can also interact with CerS2, with the interaction dependent on both proteins being catalytically active. Transfection of cells with FATP1, FATP2 or FATP4 increased ceramide levels although only FATP2 and 4 increased dihydroceramide levels, consistent with their known intracellular locations. Finally, lipofermata, an FATP2 inhibitor which is believed to directly impact tumor cell growth via modulation of FATP2, decreased de novo dihydroceramide synthesis, suggesting that some of the proposed therapeutic effects of lipofermata may actually be mediated via (dihydro)ceramide rather than directly via acyl CoA generation

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Aspergillus oryzae var. oryzae   Thecamonas trahens   Helianthus annuus   phytoplankton environmental sample   Xanthomonas campestris pv. campestris str. B100   Beauveria bassiana ARSEF 2860   Dioscorea alata   Paenibacillus sp.   Dendroaspis angusticeps   Streptococcus pneumoniae SP14-BS69   Fungi   Vulpes vulpes   Trichomonas vaginalis   Streptomyces sp. EF-93   Stigmatella aurantiaca DW4/3-1   Nicotiana glauca   Aspergillus fumigatus   Vitis labrusca x Vitis riparia   Ictidomys tridecemlineatus   Brassica rapa   Paracoccus denitrificans PD1222   Syntrophobacter fumaroxidans MPOB   Blautia producta ATCC 27340 = DSM 2950   Sanghuangporus   Chromatiales bacterium OalgGamma1   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456   Momordica cochinchinensis   Lactococcus lactis subsp. lactis Il1403   Giardia lamblia ATCC 50803   Leishmania mexicana   Cyclotella cryptica   Acanthoscurria geniculata   Penicilliopsis zonata   Phaeodactylum tricornutum   Bacteroides caccae   Eucalyptus globulus   Rattus rattus   Cyclopes didactylus   Brucella melitensis   Dinoroseobacter shibae DFL 12 = DSM 16493   Meleagris gallopavo   Bacillus thuringiensis serovar kurstaki str. HD73   Spizellomyces punctatus   Lactobacillus johnsonii   Pachycladon enysii   Campylobacter jejuni   Enterobacter cloacae   Aspergillus carbonarius ITEM 5010   uncultured microorganism   Streptococcus equi subsp. equi   Streptomyces avidinii   Cavia porcellus   Aspergillus aff. niger A2   Caryophyllales   Tetrahymena thermophila   Ailuropoda melanoleuca   Salmonella bongori   Acanthamoeba castellanii   Rousettus aegyptiacus   Myzus persicae persicae   Alternaria tomato   Daphnia pulex   Ambystoma mexicanum   Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819   Chlorocebus aethiops aethiops   Carnobacterium maltaromaticum   Deinococcus deserti VCD115   Schizosaccharomyces pombe OY26   Enterococcus faecalis   Pseudomonas sp. Lz4W   Oryctolagus sp. 'Rabbit_OD'   Quercus   Mammalia   Human herpesvirus 4 type 1   Oryza sativa Indica Group   Dunaliella salina   Ascaris suum   Parasynechococcus marenigrum WH 8102   Influenza A virus (A/New Caledonia/20-JY2/1999(H1N1))   Qipengyuania flava   Laxus oneistus   Neisseria meningitidis MC58   Telmatactis   Bienertia sinuspersici   Allexis   Elizabethkingia anophelis   Plasmodium falciparum 3D7   Anacardium occidentale   Brassica oleracea var. italica   Physcomitrella   Cassiopea xamachana   Geobacillus kaustophilus   Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150   Nicotiana sylvestris   Stagonospora   Tetrastichus   Beauveria bassiana   Gnathostoma spinigerum   Deinococcus radiodurans ATCC 13939   Musa ABB Group   Capreolus capreolus   Populus tremula x Populus tremuloides   Desulfovibrio sp. G11   Thalassiosira pseudonana   Brucella abortus   Buddenbrockia plumatellae   Lagenaria siceraria   Staphylococcus aureus subsp. aureus USA300_TCH1516   Phaseolus vulgaris   Fusarium graminearum GZ3639   Helicobacter pylori A45   Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291   Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2   Crustacea   Aedes aegypti aegypti   Chlorella sp. SAG 211-18   Ursus deningeri   Olavius algarvensis Delta 1 endosymbiont   Conus betulinus   Coprococcus sp. ART55/1   Malassezia sympodialis ATCC 42132   Mycobacterium tuberculosis SP7   Frankia coriariae   Cleome angustifolia   Eryx colubrinus loveridgei   Bubalus bubalis   Viola odorata   Lingula anatina   Paracoccidioides lutzii Pb01   Haloferax volcanii DS2   Chitinophaga pinensis   Acinetobacter sp. PM-14   Thermus thermophilus   Crotalus horridus   Crotalus durissus terrificus   Arvicola   Ursus maritimus   Equisetum arvense   Acanthamoeba castellanii str. Neff   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028s Wu   Anser cygnoides   Saiga tatarica   Halobacterium salinarum R1   Equus caballus   Schmidtea mediterranea   Coronavirus PREDICT CoV-2   Lilium   Tarenaya hassleriana   Olavius algarvensis Delta 4 endosymbiont   Nostoc punctiforme PCC 73102   Trypanosoma cruzi strain CL Brener   Pseudotsuga menziesii   Myxobolus wulii   Diploria labyrinthiformis   Synechocystis sp.   Toxoplasma gondii RH   Corynebacterium diphtheriae bv. mitis str. ISS 3319   Corynebacterium diphtheriae NCTC 13129   Thalassiosira pseudonana CCMP1335   Candidatus Glomeribacter   Thermothelomyces heterothallicus   Drosophila melanogaster   Dickeya solani   Levilactobacillus brevis   Simulium damnosum s.l. Me1   Haemophilus influenzae   Aspergillus   Oenothera glazioviana   Amycolatopsis mediterranei S699   Tropilaelaps mercedesae   unidentified marine bacterioplankton   Carica papaya   Pyricularia oryzae   Pseudomonas syringae   uncultured Clostridium sp.   Mus musculus   Tuber indicum   Rickettsia conorii str. Malish 7   Severe acute respiratory syndrome coronavirus 2   Litoditis marina   Pyrococcus furiosus   Asterias rubens   Arabidopsis thaliana   Melioribacter roseus P3M-2   Callinectes sapidus   Tubastraea coccinea   Nannochloropsis oceanica strain IMET1   Nicotiana benthamiana   Lactobacillus crispatus   Bacteroides thetaiotaomicron VPI-5482   Arachis hypogaea   Mycobacteroides abscessus ATCC 19977   Myxococcus xanthus DZ2   Ustilago maydis   Synechocystis sp. PCC 6803 substr. GT-S   Phytophthora capsici LT1534   Sturnus vulgaris   Candidatus Profftella armatura   Burkholderia pseudomallei K96243   Phaeobacter sp. MED193   Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14   Pseudomonas aeruginosa UCBPP-PA14   Homo   Chlamydia trachomatis 434/Bu   Phytophthora infestans   prokaryotic environmental samples   Zea mays   Coffea eugenioides   Staphylococcus sp. KDM4   Moringa oleifera   Bifidobacterium kashiwanohense PV20-2   Tetranychus urticae   Human coronavirus NL63   Ceuthophilus sp. Ceu_104_TX_San_Rattlesnake   Mesocricetus auratus   Haemonchus contortus   biofilm metagenome   Vitis hybrid cultivar   Giardia intestinalis assemblage A   Bartonella quintana   Ascoidea rubescens   Bacillus cereus   Caldanaerobacter subterraneus subsp. tengcongensis MB4   Tamias striatus   Sus scrofa domesticus   Rhizopus delemar   Conus geographus   Endozoicomonas   Anopheles stephensi   Chaetoceros sp.   Caretta caretta x Chelonia mydas   [Candida] auris   Panine betaherpesvirus 2   Thermothelomyces thermophilus ATCC 42464   (Vitis vinifera x Vitis berlandieri) x Vitis berlandieri   Channa striata   Bombus terrestris   Nepenthes ampullaria   Rattus norvegicus   Eimeria tenella   Modestobacter marinus BC501   Nannospalax galili   Pseudodiploria strigosa   Colobus guereza   Pseudomonas aeruginosa PAO1H2O   Naja sagittifera   Tomato spotted wilt orthotospovirus   Bemisia cf. tabaci Middle East-Asia Minor 1   Steinernema carpocapsae   Boiga irregularis   Lachancea waltii NCYC 2644   Picea abies   Chlorocebus sabaeus   Geobacillus kaustophilus HTA426   Arcobacter   Bursaphelenchus xylophilus   Burkholderia cenocepacia H111   Staphylococcus aureus subsp. aureus NN50   Mycobacterium avium 100   Plasmodium yoelii yoelii 17XNL   Enhydra lutris nereis   Pygoscelis adeliae   Pseudomonas putida   Amblyrhynchus cristatus   Mycobacterium tuberculosis M24   Stenotrophomonas rhizophila   Anaerostipes caccae L1-92   Myxococcus xanthus DK 1622   Malaclemys terrapin   Staphylococcus aureus subsp. aureus USA300_FPR3757   Dolichospermum circinale AWQC310F   Sycon ciliatum   Piper nigrum   Sterolibacterium denitrificans   Tuber albidum   Klebsiella variicola   Clostridioides difficile ATCC 43255   Thermococcus eurythermalis   Mycobacterium tuberculosis C StG4006   Diplonema papillatum   Manica rubida   Alicycliphilus denitrificans BC   Castor   Juglans regia   rhizosphere soil bacteria ensemble   Delonix regia   Bacillus cereus ATCC 10987   Quercus ilex   Francisella tularensis subsp. novicida U112   Aspergillus nidulans TN02A3   Trichechus manatus   Strigamia maritima   Macadamia   Luteibacter   Fusarium fujikuroi IMI 58289   Heligmosomoides polygyrus bakeri   Paenibacillus polymyxa ATCC 842   Bradyrhizobium japonicum   Architeuthis dux   Staphylococcus aureus subsp. aureus   Heterocephalus glaber   Lactococcus lactis subsp. cremoris MG1363   Tursiops truncatus   Capra hircus   Mycoplasma pneumoniae M129   Plasmodium knowlesi strain H   Acanthochromis polyacanthus   Acheta domesticus   environmental samples   Agrobacterium tumefaciens   Acinetobacter baumannii ACICU   Polytomella parva   Eulimnogammarus cyaneus   Danio rerio   Oncorhynchus tshawytscha   Amphora coffeiformis   Catenibacterium   Morganella   Coprothermobacter   Saccharopolyspora erythraea   Equus sp.   Saccharum sp.   Saccharina japonica   Listeria monocytogenes HCC23   Brachionus plicatilis   environmental samples   Elaeis guineensis   Dehalococcoides mccartyi   Roseburia   Tapirus terrestris   Bigelowiella natans   Hippopotamus amphibius   Myodes glareolus   Chelodina longicollis   Olea europaea   Camelus dromedarius   Burkholderia cenocepacia   Calicophoron daubneyi   Herpes simplex virus unknown type   Geobacter sulfurreducens PCA   Daphnia   marine plankton environmental sample   Clavibacter michiganensis subsp. michiganensis NCPPB 382   Scheffersomyces stipitis   Trypanosoma cruzi cruzi   Pseudomonas pseudoalcaligenes CECT 5344   Shigella dysenteriae   Oreochromis mossambicus   Roseobacter denitrificans OCh 114   Staphylococcus epidermidis   Coelodonta antiquitatis   Acinetobacter baumannii   Crocuta crocuta   Marchantia polymorpha   Sistrurus miliarius barbouri   Hippophae rhamnoides   Lentinula edodes   Medicago truncatula   Austrolebias   marine metagenome   Leishmania braziliensis   Pasteurella multocida subsp. multocida str. Pm70   Staphylococcus aureus subsp. aureus NCTC 8325   Saccharomyces cerevisiae EC1118   Escherichia coli K-12   soil bacterium 10G-05   Blumeria graminis f. sp. tritici   Streptomyces sp. MBT84   Brachylophosaurus canadensis   Vicia faba   Saccharomyces cerevisiae S288C   Millerozyma acaciae   Ceratopteris richardii   Murine leukemia virus isolates   Chlorella sp. FC2 IITG   Morganella   Liquorilactobacillus hordei   Plasmodium vivax Sal-1   Apostichopus japonicus   Cenchrus americanus   Theobroma cacao   Campylobacter concisus 13826   Chlamydomonas reinhardtii   Ruminiclostridium papyrosolvens DSM 2782   Spiroplasma melliferum   Dengue virus   Quercus suber   Oncorhynchus mykiss   Prochlorococcus marinus subsp. pastoris str. CCMP1986   Pachysolen tannophilus NRRL Y-2460   Algoriphagus marincola HL-49   Clostridium tetani E88   Mycobacterium tuberculosis SP13   Spodoptera frugiperda   Siphoviridae   Streptomyces griseorubens   Venturia pyrina   Pituophis melanoleucus   Aedes albopictus   Candida albicans SC5314   Legionella pneumophila subsp. pneumophila str. Philadelphia 1   Aggregatibacter actinomycetemcomitans D7S-1   Ostreococcus tauri   Schistosoma mansoni   Exidia glandulosa HHB12029   Thermococcus gammatolerans   Passiflora edulis   Listeria monocytogenes EGD-e   Bothrops neuwiedi   Pseudomonas ogarae   Thermochaetoides thermophila DSM 1495   Rickettsia akari   Phlebotomus papatasi   Parhyale hawaiensis   Clostridioides difficile 630   Plasmodium falciparum FcB1/Columbia   Caenorhabditis elegans   Acinetobacter baylyi ADP1   Rapana venosa   Eggerthella phage P3   Alces alces   Murine leukemia virus   Euzebya tangerina   Streptococcus dysgalactiae subsp. equisimilis SK1249   Chlorella vulgaris   Piscirickettsia salmonis AUSTRAL-005   Coxiella-like endosymbiont of Rhipicephalus sanguineus complex   Sus scrofa   Frankliniella sp. BIOUG14947-G11   Faecalibacterium prausnitzii   Aspergillus fumigatus Af293   Pseudomonas sp.   Pteropus rodricensis   Nicotiana quadrivalvis   Rickettsia conorii subsp. raoultii   Dreissena polymorpha   rat gut metagenome   Agaricus bisporus   Mytilus edulis   Mus musculus wagneri   Craterostigma plantagineum   Actinomycetospora chiangmaiensis DSM 45062   Epichloe festucae E2368   Galleria mellonella   Pinus radiata   Escherichia phage T7   Clostridioides difficile str. A-027   Cervus elaphus   Haberlea rhodopensis   Fomitopsis pinicola   Lysiphlebus fabarum   Sulfurihydrogenibium   Cancer irroratus   Taenia hydatigena   Peterozyma xylosa   Synechocystis sp. PCC 6803 substr. GT-I   Serendipita indica   Crotalus adamanteus   Piaractus mesopotamicus   Nicotiana plumbaginifolia   Human herpesvirus 2 strain 186   Magnaporthe sp. MG05   Sitobion avenae   Bemisia tabaci   Fusarium cf. oxysporum   Brochothrix thermosphacta   Heloderma suspectum suspectum   Nicotiana gossei   Secale cereale   Alteromonas macleodii ATCC 27126   hybrid   Coffea arabica   Dokdonia sp. MED134   Brucella abortus 104M   Pongo pygmaeus   Pinus pinaster   Lolium perenne subsp. perenne   Rhodopseudomonas palustris CGA009   Bombyx mori   Dichomitus squalens   Avicennia officinalis   Haemaphysalis longicornis   Drosophila pseudoobscura   Clostridium butyricum E4 str. BoNT E BL5262   Bothrops jararacussu   Gossypium hirsutum   Dinosauria   Xenopsylla cheopis   Candida tropicalis   Bos indicus   Herbaspirillum seropedicae   Human herpesvirus 5 strain Merlin   Mycoplasma pneumoniae   Kluyveromyces marxianus   Helicobacter pylori 26695-1   Paulownia   Latrodectus hesperus   Myzus persicae   Orbicella annularis   Leishmania tarentolae   Gallus   Legionella pneumophila   Amaranthus tricolor   Lacticaseibacillus rhamnosus   Bacillus cereus AH187   Acetomicrobium mobile   Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11   Streptococcus pyogenes   Sparus aurata   Oryctolagus cuniculus   Gadus morhua   Methanothrix   Saccostrea glomerata   Mycobacterium tuberculosis LAM7   Heliocidaris erythrogramma   Bacillus mycoides DSM 2048   Oscillatoriaceae cyanobacterium   Vibrio anguillarum   Malassezia sympodialis   Salmonella enterica subsp. enterica serovar Typhimurium   Colobanthus quitensis   Paracentrotus lividus   Aeromonas salmonicida subsp. salmonicida   Merluccius bilinearis   Pseudoalteromonas sp. D41   Roseburia hominis A2-183   Ictalurid herpesvirus 1   Thermodesulfobium acidiphilum   Lingulodinium polyedra   Serpentes sp. WLS21042014   Clostridioides difficile R20291   Hyalella azteca   Saccharomyces cerevisiae YJM789   Tilletia indica   Apteronotus leptorhynchus   Triaenophorus crassus   Sorghum bicolor x Saccharum hybrid cultivar   Fusarium oxysporum f. sp. lycopersici   Streptococcus mutans UA159   Lobaria pulmonaria   Betacoronavirus sp.   Trichoderma sp. 1 YW-2011   Nicotiana bonariensis   Manduca sexta   Bacillus pumilus   Ianthella basta   Tuber aestivum   Rheum palmatum   Ursus arctos   Fragaria x ananassa   Orycteropus afer   Physalis angulata   Avena sativa   Clostridioides difficile   Micrurus fulvius   Lagomorpha   Pseudomonas aeruginosa LESB58   Roseburia intestinalis L1-82   Pyrenochaeta sp.   Capsaspora owczarzaki   Dasypogon diadema   Ruminiclostridium cellulolyticum H10   Halomonas sp.   Aspergillus flavus partitivirus 1   [Ruminococcus] gnavus   Rhipicephalus sanguineus complex sp. ME-2011   Mycobacterium tuberculosis SP10   Euglena gracilis   Thermoanaerobacter pseudethanolicus   Drosophila simulans   Aspergillus flavus FRR 342   Saccharomyces cerevisiae   Candidatus Methylomirabilis oxyfera   Sedum plumbizincicola   Rhizorhabdus wittichii   Argulus foliaceus   Ovis aries   Fagus grandifolia   Sinopodophyllum hexandrum   Escherichia coli O157:H7 str. TW14359   Clostridia   Nicotiana glutinosa   Granulicatella adiacens ATCC 49175   Yersinia enterocolitica   Streptococcus suis SC84   Medicago truncatula var. truncatula   Acanthamoeba polyphaga   Populus cathayana   unidentified chimeric sequence   Zymoseptoria tritici IPO323   Human alphaherpesvirus 1   Vitis   Labeo rohita   Xylocopa violacea   Anopheles gambiae   Bicyclus anynana   Dictyostelia   Solenopsis invicta   Naja naja   Flavivirus   wastewater metagenome   Arion vulgaris   Veillonella parvula DSM 2008   Saccharum hybrid cultivar x Sorghum bicolor   Clostridium autoethanogenum   Cylindrospermopsis raciborskii CS-509   Pogona vitticeps   Komagataella pastoris DSMZ 70382   Plasmodium yoelii   Streptomyces lividans TK24   Guillardia theta   Vulpes lagopus   Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940   Cellulophaga baltica NN016038   Syntrophus aciditrophicus   human gut metagenome   Malassezia pachydermatis   Naja mandalayensis   Influenza A virus (A/Wilson-Smith/1933(H1N1))   Saccharum hybrid cultivar   Rhipicephalus microplus   Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841   Vaccinia virus   Sulfolobus islandicus REY15A   Trypanosoma brucei brucei TREU927   Cryptosporidium parvum   Spondylus gaederopus   Thermococcus gammatolerans EJ3   Trichoderma reesei RUT C-30   [Candida] glabrata CBS 138   Serpentes   Pinus taeda   Pseudomonas aeruginosa PA14   Cupriavidus basilensis   Helicoverpa armigera   Pseudomonas aeruginosa PAO1   Anopheles gambiae str. PEST   Streptococcus thermophilus LMD-9   Candidatus Margulisbacteria   Lactococcus lactis subsp. cremoris UC509.9   Mycoplasma pneumoniae 19294   Citrobacter freundii   Erysipelatoclostridium ramosum DSM 1402   Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10   Bacillus altitudinis   Norovirus   Naegleria fowleri   Frankia alni   Entamoeba histolytica HM-1:IMSS   Neosciurus carolinensis   Pomacea canaliculata   Acesta excavata   Lactobacillus iners   Opsanus beta   Liberibacter endosymbiont of Diaphorina citri   Mucidula mucida   Influenza A virus   Volvariella volvacea V23   Durusdinium trenchii   Tepidanaerobacter acetatoxydans   Streptococcus pneumoniae   Hyphomicrobium sp. MC8b   environmental samples   Kuraishia capsulata   Pseudomonas taiwanensis   Octopus vulgaris   Schizophyllum commune H4-8   Coffea canephora   Entamoeba histolytica HM-1:IMSS-B   Triatoma sordida   Nicotiana repanda   Rhodothermus marinus DSM 4252   Trichomonas gallinae   Cupriavidus necator N-1   Pongo abelii   Nicotiana langsdorffii   Toxoplasma gondii GT1   Panicum virgatum   Citrus sinensis   Anaerococcus hydrogenalis DSM 7454   Trichodesmium erythraeum IMS101   Pedobacter sp.   Bordetella pertussis   Tannerella forsythia   Coprothermobacter proteolyticus   Candidatus Paraburkholderia kirkii   Flavobacterium columnare   Ictidomys tridecemlineatus arenicola   Glossina morsitans   Streptococcus pyogenes M1 GAS   Methanosarcina acetivorans   Conus striatus   Riptortus pedestris   Breviolum minutum   Jatropha curcas   artificial sequences   Francisella tularensis   Mammuthus sp.   Martes martes   Pseudomonas sp. 'Pseudom. M1'   Nicotiana clevelandii   Mycobacterium tuberculosis KZN 1435   Mammut americanum   Arbacia punctulata   Eucalyptus spp. mixed library   Streptococcus mutans 19   Helicobacter pylori H13-1   Pseudomonas fluorescens SBW25   Cryptococcus neoformans var. grubii H99S   Haemophilus influenzae Rd KW20   Candida dubliniensis CD36   Amphimedon   Shewanella baltica   Toxoplasma gondii PRU   Conus zonatus   Trichinella britovi   Mycobacterium tuberculosis variant bovis AN5   Chenopodium quinoa   Dehalococcoides mccartyi CG1   Thermus thermophilus HB8   Nostoc sp. FB71   HIV-1 vector pNL4-3   Mammuthus primigenius   Pyricularia oryzae B157   Meyerozyma guilliermondii   Pleuromamma xiphias   Corucia zebrata   Russula atropurpurea   Olavius algarvensis spirochete endosymbiont   Archaea   Aeromonas sp. enrichment culture clone AM2   Pectobacterium carotovorum   Ctenopharyngodon idella   Azospirillum brasilense FP2   Mollivirus sibericum   Amycolatopsis   Clostridium cellulovorans 743B   Gulo gulo   Oryzias latipes   environmental samples   Streptomyces lincolnensis   Ophrys garganica   Nosema apis   Bothrops cotiara   Fusarium oxysporum f. sp. cucumerinum   unclassified Marseilleviridae   Orthopoxvirus   Passer domesticus domesticus   Lentinus crinitus   Candidatus Endoriftia persephone   Cairina moschata   Homo sapiens subsp. 'Denisova'   Neisseria meningitidis FAM18   Tremarctos ornatus   Pseudomonas composti   Marchantia polymorpha subsp. ruderalis   Megoura viciae   Dichocoenia stokesii   Dryopteris affinis subsp. affinis   Exiguobacterium sp. SH31   Fraxinus mandshurica   Pristhesancus sp. 00004635   Chryseobacterium indologenes   Lactococcus lactis   Flavobacterium sp. 316   Lachancea kluyveri   Culex pipiens pipiens   Lacticaseibacillus rhamnosus GG   Cecropia peltata   Mahonia   Struthio camelus   Roseburia inulinivorans DSM 16841   Sarcoptes scabiei   uncultured Desulfobacterium sp.   Podospora anserina S mat+   Rhynchocyon petersi   Vairimorpha necatrix   Botrytis cinerea T4   Treponema   Micrococcus luteus   Lithobius forficatus   Vibrio cholerae O1 str. VC91   Limosilactobacillus mucosae LM1   Garcinia mangostana   Marseillevirus   Saccharomyces mikatae IFO 1815   Mytilus edulis/galloprovincialis MCLGV-2007   Echinococcus granulosus   Prochlorococcus marinus str. MIT 9313   Cyberlindnera jadinii   Tuber melanosporum Mel28   Pseudoliparis swirei   Colinus virginianus   Dioscorea oppositifolia   Planctopirus limnophila DSM 3776   Trypanosoma cruzi Dm28c   Naja oxiana   Gorilla gorilla   Acinetobacter calcoaceticus/baumannii complex   [Candida] glabrata   [Candida] boidinii   Synechococcus phage S-SSM7   Acinetobacter baumannii AB307-0294   Streptococcus pyogenes ABC020006030   Lactococcus phage   Harmonia axyridis   Larimichthys crocea   Candidatus Accumulibacter   Crassostrea gigas   Staphylococcus sp. 1   Butyrivibrio proteoclasticus B316   Brugia malayi   Haloferax volcanii   Nicotiana paniculata   Tequatrovirus T4   fungal sp. 5OL6-6PL1   Listeria monocytogenes EGD   Acholeplasma laidlawii PG-8A   Cervus nippon hortulorum   Onchocerca lupi   sediment metagenome   Phaeodactylum tricornutum CCAP 1055/1   Ipomoea batatas   Hevea brasiliensis   Salmonella enterica subsp. enterica serovar Typhimurium str. D23580   Pichia kudriavzevii   Tachaea chinensis   Rhodnius prolixus   Francisella orientalis FNO12   Linnemannia elongata AG-77   Staphylococcus aureus subsp. aureus COL   Zalophus californianus   Agkistrodon piscivorus   unclassified Candidatus Omnitrophica   Sulfobacillus thermosulfidooxidans   Secale cereale x Triticum turgidum subsp. durum   Crocosphaera subtropica ATCC 51142   Tritrichomonas foetus   Antidorcas marsupialis   Geodermatophilus obscurus DSM 43160   Dolichospermum circinale AWQC131C   Rupicapra pyrenaica   Rhinocerotidae   Nelumbo nucifera   Solidesulfovibrio magneticus RS-1   Sepioloidea lineolata   Brassica carinata   Dendroaspis polylepis polylepis   Hypsiglena jani   Trypanosoma vivax Y486   Leishmania major   Aspergillus sydowii   Nakazawaea wickerhamii   Gorilla gorilla gorilla   Yarrowia lipolytica   Staphylococcus lugdunensis   Anguilla anguilla   Orthomyxoviridae   Aspergillus brasiliensis   Actinoplanes sp. SE50/110   Papaver somniferum   Lactiplantibacillus plantarum subsp. plantarum   anaerobic digester metagenome   Mycoplasma feriruminatoris   Geobacillus sp. WSUCF1   Rhizobium leguminosarum bv. phaseoli CCGM1   Dickeya dadantii subsp. dadantii   Brucella   Paramecium tetraurelia   Pseudomonas stutzeri   Xanthomonas translucens   Zymomonas mobilis   Cryptochiton stelleri   Porphyromonas gingivalis W83   Brassica oleracea var. gemmifera   Nitrospirillum amazonense CBAmc   Trypanosoma   Helicobacter pylori E48   Pseudomonas putida F1   Colwellia psychrerythraea 34H   Sorghum bicolor   Mycobacterium marinum   Toxoplasma   Pseudomonas putida KT2440   Cowpox virus (Brighton Red)   Lactobacillus   Mycobacterium tuberculosis TKK-01-0032   Ebolavirus   Emiliania huxleyi   Verticillium dahliae JR2   Mycobacterium tuberculosis variant bovis str. Ravenel   Bothrops moojeni   Histomonas meleagridis   Alligator mississippiensis   Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044   Papio hamadryas   Streptococcus thermophilus   Nostoc sp. PCC 7120 = FACHB-418   Toxoplasma gondii type III   Pisum sativum   Strix varia   Rhodospirillum rubrum ATCC 11170   Pseudo-nitzschia delicatissima   Megaloceros giganteus   Bactrocera dorsalis   Synechococcus elongatus   Leishmania donovani BPK282A1   Beauveria bassiana CGMCC 7.34   Acinetobacter baumannii D1279779   Methanobrevibacter cuticularis   Apis mellifera   Onchocerca ochengi   Daphnia magna   Human alphaherpesvirus 1 strain 17   Aplysia californica   Haemophilus haemolyticus   Citrobacter rodentium   Pan troglodytes   Crunoecia irrorata   Avian infectious bronchitis virus (strain Beaudette CK)   Nitrospinae   Giardia sp.   Salmonella enterica subsp. enterica serovar Typhimurium str. ST1489   Ornithodoros erraticus   Gasterosteus aculeatus   Hydrolagus colliei   Aedes aegypti   Populus tremula x Populus alba   Botrytis cinerea   Halomonas sp. TD01   Ophrys sphegodes   Bos grunniens   Cellulomonas gilvus ATCC 13127   Sophora alopecuroides   Staphylococcus aureus subsp. aureus str. Newman   Giardia intestinalis   Anas platyrhynchos   Emiliania   Saccharomyces cerevisiae BY4741   Rickettsia slovaca 13-B   Strongyloides venezuelensis   Bacillus anthracis str. Sterne   Aspergillus flavus NRRL3357   Biomphalaria glabrata   Mycoplasma gallisepticum   Citrullus lanatus   Bifidobacterium pseudolongum   Ursus americanus   Frankia alni ACN14a   Tilletia laevis   Human coronavirus HKU1   Amblyomma americanum   Filifactor alocis   Gorilla   Brenneria nigrifluens   Hydra vulgaris   Strawberry leafy fruit phytoplasma   Phytophthora capsici   Plum pox virus   Human herpesvirus 5 strain AD169   Gossypium   Klebsiella pneumoniae MGH 78578   Solanum lycopersicum x Solanum tuberosum   Streptomyces venezuelae   Rangifer tarandus   Bacillus pseudomycoides DSM 12442   Nicotiana benavidesii   Eriocheir sinensis   Trypanosoma cruzi strain Esmeraldo   Bacillus weihenstephanensis   Physcomitrium patens   Plasmodium falciparum Dd2   Afrohybanthus enneaspermus   Faustovirus   Synechococcus sp. BL107   Thalassiosira oceanica CCMP1005   Helicobacter pylori J99   Leishmania donovani   Streptomyces coelicolor   Euterpe oleracea   Microcystis aeruginosa   Panthera leo   Loxodonta africana   Enterococcus faecium   Leishmania mexicana MHOM/GT/2001/U1103   Roseobacter sp. MED193   Francisella tularensis subsp. holarctica LVS   Bacillus sp. 142311   Babjeviella inositovora   Colon   Myxobolus honghuensis   Helianthus tuberosus   Candidatus Pelagibacter ubique   Felis catus   Nerodia clarkii   Solanum tuberosum   Rosaceae   Coccinia grandis   Desulfoluna spongiiphila   Quercus petraea   Vibrio harveyi   Rhizobium sp. CIAT652   Sulfolobus acidocaldarius   Desmodesmus subspicatus   Candida parapsilosis   Buchnera aphidicola (Acyrthosiphon pisum)   Botrytis cinerea B05.10   Bartonella quintana JK 31   Pyrus x bretschneideri   Panopea generosa   Burkholderia cenocepacia K56-2Valvano   Burkholderia ubonensis MSMB22   Hepatitis C virus genotype 1   Dentex dentex   Helicobacter pylori 26695   Nilaparvata lugens   Cellulophaga baltica 18   Bithynia siamensis goniomphalos   Microbacterium oxydans   Equus asinus africanus   Camponotus fellah   Oryza sativa   Panthera tigris   Tetrahymena thermophila CU428   Acanthamoeba polyphaga mimivirus   Neospora caninum   Methanosarcina mazei Go1   Ustilaginoidea virens   Trichinella pseudospiralis   Bothrops insularis   Dactylorhiza   Leucoraja erinacea   Paradendryphiella salina   Equus asinus   Petunia x hybrida   Shigella flexneri 2a str. 2457T   Nicotiana noctiflora   Avena strigosa   Malus domestica   Roseibaca calidilacus   Dorea longicatena DSM 13814   Trametes versicolor   Ophrys x arachnitiformis subsp. archipelagi   Gardnerella vaginalis   Chlamydia trachomatis   Coprococcus comes ATCC 27758   Leishmania sp. MHOM/IN/80/DD8   Clostridium phage c-st   Cereibacter sphaeroides 2.4.1   Brassica oleracea   Sordaria macrospora   Mucilaginibacter   Human betaherpesvirus 5   HIV-1 M:G_PT919   Plasmodium falciparum   Aspergillus tubingensis   Tetraponera aethiops   Stenotrophomonas maltophilia   Nematostella vectensis   Streptococcus pneumoniae R6   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2   Scutigera coleoptrata   Schistosoma haematobium   Rhodobacter capsulatus SB 1003   Chara australis   Viruses   Chlamydomonas reinhardtii CC3269   Angiostrongylus cantonensis   Cylindrospermopsis raciborskii CS-506   Diplazium maximum   Lathyrus sativus   Microcystis aeruginosa PCC 7806   Hypsizygus marmoreus   Hominidae   Thermoclostridium stercorarium   Legionella pneumophila str. Paris   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581   Wheat dwarf virus - [Taiyuan]   Nicotiana longiflora   Fusobacterium nucleatum subsp. nucleatum ATCC 25586   Oryza australiensis   Rosa chinensis   Serratia inhibens PRI-2C   Pseudoalteromonas flavipulchra NCIMB 2033 = ATCC BAA-314   Trifolium pratense subsp. pratense   Toxoplasma gondii   Carnobacterium divergens   Vibrio alginolyticus   Mentha spicata   Amphibalanus amphitrite   Osphranter rufus   Pseudomonas aeruginosa LESlike1   Craterostigmus tasmanianus   Sulfuritalea   Nepenthes x hookeriana   Latilactobacillus curvatus   Halobacterium   Nepenthes rafflesiana   Mariprofundus ferrooxydans   Salmonella enterica subsp. enterica serovar Enteritidis str. P125109   Cancer   Lentibacter algarum   Streptococcus agalactiae   Viola   Schizosaccharomyces pombe 972h-   Desulfovibrio ferrophilus   Cuniculiplasma divulgatum   Lens culinaris   Staphylococcus xylosus   Camellia sinensis   Brucella anthropi ATCC 49188   Equidae   Clostridium butyricum DSM 10702   Lecanicillium fungicola var. fungicola   Rickettsia massiliae MTU5   Klebsiella pneumoniae ATCC BAA-2146   Tetronarce californica   Aspergillus versicolor   Enchytraeus crypticus   Olavius algarvensis sulfate-reducing endosymbiont   Leishmania tropica   Cryptosporidium andersoni   Mycoplasma gallisepticum S6   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088   Tribolium castaneum   Capra ibex   Escherichia coli HT115   Synechococcus phage syn9   Cuon alpinus   Aspergillus nidulans FGSC A4   Candida parapsilosis CDC317   Methanothermobacter thermautotrophicus   Cricetulus griseus   Lymnaea stagnalis   Synechococcus sp. YX04-3   Malassezia furfur   Quercus robur   Wolbachia pipientis wMelCS   Bothrops brazili   Bartonella henselae   Francisella tularensis subsp. holarctica FSC200   Bacillus toyonensis BCT-7112   Rupicapra rupicapra   Meandrina meandrites   Lutra lutra   Noccaea caerulescens   Malassezia globosa   Human immunodeficiency virus type 1 3916-CRO   Ophiophagus hannah   Pogostemon cablin   Coxiella burnetii RSA 493   Corynebacterium glutamicum ATCC 13032   soil bacterium TS1114R   Spinacia oleracea   Polaribacter marinivivus   Rickettsia rickettsii   Tyrannosaurus rex   Amblyomma cajennense   Selaginella moellendorffii   Eubacterium limosum   Lynx lynx   Notamacropus eugenii   Oryctolagus cuniculus cuniculus   Bivalvia   Shigella sonnei 53G   Yersinia pestis   Corynebacterium glutamicum K051   Burkholderia pseudomallei 1026b   Mytilus sp. CHGF4   Caballeronia mineralivorans   Ogataea polymorpha   Streptococcus uberis   Salmo sp.   Eukaryota   Neospora caninum Liverpool   Spiroplasma melliferum KC3   Galloanserae   Borreliella burgdorferi B31   Novosphingobium nitrogenifigens   Influenza B virus (B/Memphis/13/2003)   Picea likiangensis var. rubescens   Sinorhizobium americanum   Sepia officinalis   Fraxinus nigra   Pogonomyrmex rugosus   Plutella xylostella   Taenia solium   Viridiplantae   Aspergillus fumigatus CEA10   Klebsiella pneumoniae LCT-KP289   Dendrobium huoshanense   Enterococcus faecium DO   Sorangium cellulosum So ce56   Ruegeria pomeroyi   Moneuplotes crassus   Tuber magnatum   Plasmodium berghei   Bovine leukemia virus   Minona ileanae   Populus tomentosa   Pseudomonas phage EL   Listeria monocytogenes   Human immunodeficiency virus   Candida albicans   Thalassiosira oceanica   Paucilactobacillus suebicus   Faecalibacterium prausnitzii SL3/3   Musa acuminata AAA Group   Photobacterium profundum SS9   mixed culture metagenome   Schistocephalus solidus   Daktulosphaira vitifoliae   Pseudovibrio sp. FO-BEG1   Muvirus mu   Paulownia fortunei   Mycobacterium avium subsp. paratuberculosis K-10   Halorubrum lacusprofundi ATCC 49239   Schizosaccharomyces pombe   Mycobacteroides abscessus   Puccinellia tenuiflora   Acyrthosiphon pisum   Salmonella enterica subsp. enterica serovar Cerro   Cellvibrio japonicus Ueda107   Firmicutes   Hadronyche infensa   Acidiphilium cryptum JF-5   Caulobacter vibrioides NA1000   Toxoplasma gondii CtCo5   Tremella   Strigomonas culicis   Lactobacillus johnsonii N6.2   Tradescantia spathacea   Dionaea muscipula   Meles meles   Acidipropionibacterium acidipropionici   Gelatoporia subvermispora   Aspergillus terreus   Mycoplasma hyopneumoniae 232   Pseudomonas fluorescens   Brassica napus   microbial mat metagenome   Mycoplasma pneumoniae M129-B7   Petunia   Serratia phage JS26   Escherichia coli   H1N1 subtype   Citeromyces matritensis   Tetrahymena thermophila SB210   Gammarus roeselii   Corallochytrium limacisporum   Anneissia japonica   Aspergillus niger NRRL3   Methanohalophilus   Stegodyphus mimosarum   Agrostis stolonifera   Paenibacillus pabuli   Clostridium botulinum A str. Hall   Paenibacillus amylolyticus   Neisseria gonorrhoeae   Penicillium sp. B12   Solanum lycopersicum   Moraxella catarrhalis   Listeria monocytogenes serotype 4b str. F2365   Toxoplasma gondii ME49   Mycolicibacterium smegmatis MC2 155   Orbicella faveolata   cf. Chlorella sp.   Leptospirillum   Crassostrea hongkongensis   Cupiennius salei   Cajanus cajan   Japanese encephalitis virus   Morchella importuna   Paramoeba perurans   Mustela putorius furo   Ovis   Armoracia rusticana   Mycoplasmopsis bovis HB0801   Candidatus Midichloriaceae   Pseudomonas putida BIRD-1   Peniophora incarnata   Escherichia coli O157:H7 str. EDL933   Cyanophora paradoxa   Bodo saltans   Anisakis simplex complex   Xanthomonas campestris   Cowpox virus   Planococcus halocryophilus Or1   Homo sapiens   Populus tremula   Bacillus subtilis subsp. subtilis str. 168   Brucella abortus S19   Pichia fermentans   Pinus nigra   Bradyrhizobium diazoefficiens USDA 110   Acanthaster planci   Nosema ceranae   Komagataella pastoris   Aspergillus flavus   Bothrops leucurus   Escherichia phage vB_EcoP_SU10   Brassica oleracea var. botrytis   Entamoeba histolytica   Bordetella parapertussis   Bacteria incertae sedis   Nephila clavipes   Escherichia coli BL21(DE3)   Viola tricolor   Gossypium robinsonii   Acipenser transmontanus   Camponotus floridanus   Capsicum annuum   Eubacterium maltosivorans   Prevotella intermedia ATCC 25611 = DSM 20706   Santalum album   Anopheles culicifacies B   Salmonella enterica subsp. enterica serovar Typhimurium str. 5579   Blumeria hordei DH14   Artemisia annua   gut metagenome   Toxoplasma gondii GAB3-2007-GAL-DOM9   Methanothermococcus thermolithotrophicus DSM 2095   Bacillus amyloliquefaciens   Cucumber mosaic virus   Myotis ricketti   Rhizobium favelukesii   Sinorhizobium americanum CCGM7   Cricetulus barabensis   Nelumbo nucifera subsp. nucifera   Syntrophus aciditrophicus SB   Wolbachia sp. wMelPop   Thalassiosira cf. oceanica   Candidatus Kuenenia stuttgartiensis   Cutibacterium acnes SK137   Rhodococcus jostii RHA1   Paraconiothyrium   Mustela sp.   Taeniopygia guttata   Macaca fascicularis fascicularis   Lineus longissimus   Staphylococcus aureus   Mayaro virus (strain Brazil)   Saccharomyces cerevisiae W303   Acinetobacter baumannii CI79   Nicotiana alata   Heterosigma akashiwo   Hepatitis E virus type 1   Tropheryma whipplei TW08/27   Campylobacter fetus subsp. fetus 82-40   Streptococcus suis   Camelidae   Aerococcus urinae NBRC 15544 = CCUG 36881   Nostoc flagelliforme   Aspergillus niger CBS 513.88   Acinetobacter baumannii AB5075   Aeropyrum pernix K1   Aeropyrum pernix   Saimiri boliviensis boliviensis   Acinetobacter nosocomialis   Leishmania braziliensis MHOM/BR/75/M2904   Microbiota   Nitrospira moscoviensis   Micrurus tener   Metarhizium robertsii   Pseudotsuga menziesii var. menziesii   Human alphaherpesvirus 1 strain KOS   Phascolarctos cinereus   unidentified   Deinococcus radiodurans R1   Ectocarpus siliculosus   Leptopilina   Musa   Dehalococcoides mccartyi CBDB1   Euprymna scolopes   environmental samples   Coprococcus eutactus   Corynebacterium diphtheriae   Homo sapiens/Mus musculus xenograft   Brevibacterium casei   Aepyceros melampus   Dugesia japonica   Fusarium sp.   Neurospora crassa   Alteromonadales   bioreactor sludge metagenome   Dimocarpus longan   Populus yunnanensis   Ictalurus punctatus   Cyanidioschyzon merolae   Klebsiella pneumoniae BIDMC 40   Bacillus cereus ATCC 14579   Synechococcus elongatus PCC 7942 = FACHB-805   Chinchilla lanigera   Ciona intestinalis   Saccharolobus solfataricus   Corynebacterium glutamicum   Strongylocentrotus purpuratus   Oryctolagus cuniculus algirus   Dirofilaria immitis   Cupriavidus metallidurans   Thermococcus kodakarensis KOD1   Oleidesulfovibrio alaskensis G20   Coxiella burnetii   Mycolicibacterium smegmatis   Haptophyta   Bothrops asper   Perkinsus marinus   Scophthalmus maximus   Madurella mycetomatis   Axis axis   Ganoderma lingzhi   Prevotella bryantii B14   Methermicoccus shengliensis DSM 18856   Methanospirillum hungatei JF-1   Liquorilactobacillus nagelii   Streptomyces sp.   Burkholderia sp. 2332   Riftia pachyptila   Sistrurus catenatus   Candidatus Protochlamydia amoebophila UWE25   synthetic construct   Influenza A virus (H1N1)   Influenza A virus (A/California/07/2009(H1N1))   Manihot esculenta   Acidithiobacillus ferrooxidans ATCC 53993   Hordeum vulgare   Botryococcus braunii   Hebomoia glaucippe   Dehalobacter restrictus   Pachycladon novaezelandiae   Haliotis discus hannai   Rhizobium cf. leguminosarum   Fusarium graminearum PH-1   Cryptococcus neoformans var. grubii H99   Sphingobium chlorophenolicum   Escherichia coli O157:H7   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S   Methanoculleus sp. 10   Marthasterias glacialis   Clostridium perfringens   Bacillus thuringiensis Bt407   Brucella abortus 2308   Spongospora subterranea   Litoricola marina   Crithidia fasciculata   Prochlorococcus marinus str. MIT 9312   Klebsiella pneumoniae   Apis mellifera ligustica   Cercopithecidae   Apis mellifera pomonella   Desulforapulum autotrophicum HRM2   Datura stramonium   Ustilago maydis virus P4   Salmonella enterica subsp. enterica serovar Typhimurium str. A130   Chaetodon lunulatus   Burkholderia thailandensis   Acinetobacter sp.   Pseudomonas aeruginosa   Fusarium graminearum   Thermosynechococcus vestitus BP-1   Blastococcus saxobsidens   Candidatus Thiosymbion oneisti   Trichoderma reesei QM9414   Human immunodeficiency virus 1   Trichoplax sp. H2   Ursus arctos arctos   Leishmania infantum   Musa acuminata subsp. acuminata   Klebsiella variicola At-22   Streptococcus pyogenes STAB901   Gammarus fossarum   Penaeus vannamei   Escherichia coli str. K-12 substr. MG1655   Aspergillus aculeatus ATCC 16872   Nephotettix cincticeps   Spirometra erinaceieuropaei   Pachysolen tannophilus   Rhizoctonia solani AG-8 WAC10335   Afipia carboxidovorans   Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499   Musa AAB Group   Bradyrhizobium   Klebsiella pneumoniae JH1   Breviatea   Wolbachia endosymbiont of Diaphorina citri   Ixodes ricinus   Priestia megaterium DSM 319   Bungarus   Synechococcus sp. PCC 7002   Vespula vulgaris   Aliivibrio fischeri   Campylobacter concisus UNSWCD   Mus   Lasius niger   Castor fiber   Cynodon dactylon   Vipera berus berus   Bradyrhizobium diazoefficiens   uncultured marine microorganism   Pisolithus tinctorius Marx 270   Platichthys flesus   Glycine soja   Acinetobacter baumannii ATCC 17978   Lactiplantibacillus plantarum JDM1   Modiolus kurilensis   Crocuta   Ralstonia solanacearum GMI1000   Glycine max x Glycine soja   mixed sample   Mus musculus musculus x Mus musculus castaneus   Neisseria gonorrhoeae FA 1090   Thelohanellus kitauei   Peromyscus leucopus   Saccharomycopsis capsularis   Mycobacterium tuberculosis variant bovis   Nicotiana rustica   Mycoplasmopsis agalactiae   Plasmodium vivax   Aggregatibacter actinomycetemcomitans   Staphylococcus aureus subsp. aureus MRSA252   Ferroplasma   Brassica oleracea var. capitata   Mycobacterium tuberculosis CAS   Caprinae   Leishmania amazonensis   Hendra virus horse/Australia/Hendra/1994   Prunus avium   Yersinia ruckeri   Oryza longistaminata   Cupriavidus pinatubonensis JMP134   Porphyromonas gingivalis ATCC 33277   Rhizobium leguminosarum bv. viciae   Glia   Listeria phage A118   Synechocystis sp. PCC 6803   Pseudodiploria clivosa   Loxosceles intermedia   Xanthomonas retroflexus   Candidatus Accumulibacter phosphatis   Aspergillus giganteus   uncultured soil microorganism   Tannerella forsythia 92A2   [Ruminococcus] gnavus ATCC 29149   Ficus carica   Cervus elaphus elaphus   Nitrososphaera viennensis   Polypodium hydriforme   Oenococcus oeni   Trypanosoma cruzi   Globicatella sanguinis   Streptomyces coelicolor A3(2)   Schizosaccharomyces pombe DM3650   Mycoplasma suis KI3806   Cyanobacterium stanieri   Olavius algarvensis Gamma 1 endosymbiont   Streptococcus pneumoniae TIGR4   Escherichia coli O157:NM   Francisella tularensis subsp. holarctica   Macaca nemestrina   Dialister   Methylorubrum extorquens DM4   Montastraea cavernosa   Streptococcus pneumoniae D39   Palaemonetes sp. common grass shrimp associated circular virus   Laodelphax striatellus   Aves   Pachycladon exile   Tepidimicrobium xylanilyticum   Canis lupus x Canis lupus familiaris   Soa   Bifidobacterium longum NCC2705   Trichoderma reesei QM6a   Bacillus subtilis   Candidatus Nitrospira inopinata   Drosophila mauritiana   Komagataella phaffii   Chlorocebus aethiops   Brachypodium distachyon   Python molurus   Epstein-barr virus strain p3hr-1   Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344   Andreprevotia sp. IGB-42   Shewanella oneidensis MR-1   Desulforamulus reducens MI-1   Stappia stellulata DSM 5886   Ixodes scapularis   Prevotella ruminicola 23   Boehmeria nivea   Cervus nippon nippon   Bacillus mycoides NBRC 101238 = DSM 11821   Heterorhabditis megidis   Klebsiella pneumoniae ATCC 43816   Rhizophagus irregularis   Capsicum annuum var. annuum   Alcaligenes faecalis   Eucalyptus   Hepatitis B virus   Sinorhizobium meliloti BL225C   Sciuridae   Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759   Actinidia chinensis var. chinensis   Angiostrongylus vasorum   Synechocystis sp. PCC 6803 substr. Kazusa   Cyprinodon variegatus   Syntrophomonas wolfei   Palaemon carinicauda   Pyrococcus abyssi   Broussonetia papyrifera   Rhodopseudomonas palustris   Hippoglossus hippoglossus   Streptococcus agalactiae FSL S3-026   Natronomonas pharaonis DSM 2160   Eimeria acervulina   Ambrosiozyma philentoma   Ovis canadensis mexicana   Lipomyces starkeyi   Phytophthora pisi   Plasmodium berghei ANKA   Populus trichocarpa   Phikzvirus phiKZ   Mycobacterium tuberculosis SP1   HIV-1 M:B_HXB2R   Cytomegalovirus   Spirochaeta sp. ELBA   Ornithodoros moubata   Bacillus thuringiensis   Mycobacterium tuberculosis H37RvAE   Anoplocephala perfoliata   Mytilus galloprovincialis   Aspergillus wentii   Mycobacterium tuberculosis SP22   Xenopus laevis   Formosa sp. Hel3_A1_48   Cloning vector pEGFP-C1   Trichoderma harzianum CBS 226.95   Zygaena filipendulae   Bartonella henselae str. Houston-1   Sphingomonas sp. Leaf257   Mengo virus   Mus musculus x Rattus norvegicus   Streptomyces sp. MBT42   Trichodesmium   Sinorhizobium meliloti   Anopheles culicifacies A   Clostridium cellulovorans   Olavius algarvensis   Sepiadarium austrinum   Acetivibrio thermocellus   Nicotiana maritima   Vigna mungo   Trypanosoma brucei brucei   Moorella thermoacetica ATCC 39073   Aedes aegypti densovirus   Lotus japonicus   Tupavirus   Leishmania guyanensis species complex   Leptospira interrogans   Viola tricolor subsp. tricolor   Deinococcus radiodurans   Microcystis aeruginosa NIES-843   Francisella tularensis subsp. tularensis   albimanus section   Erysipelothrix rhusiopathiae   Fibrobacter succinogenes subsp. succinogenes S85   environmental samples   Schizosaccharomyces pombe 927   Legionella   Granulicella sp.   Passer hispaniolensis   Halobacterium salinarum   Citrus maxima   Medicago sativa   Erythrobacter sp. HL-111   Acaryochloris marina MBIC11017   uncultured bacterium   Geobacter sulfurreducens   Influenza A virus (A/Viet Nam/1203/2004(H5N1))   Chlamydia trachomatis D/UW-3/CX   Odontotaenius disjunctus   Pseudomonas aeruginosa PAK   Mycobacterium tuberculosis str. Beijing/W BT1   Ovis aries musimon   Gammarus pulex   uncultured Phormidium sp.   Paracoccidioides brasiliensis Pb18   Catalpa fargesii   Knufia petricola   Mycobacterium tuberculosis   Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821   Salmo salar   Metopolophium dirhodum   Mastigamoeba balamuthi ATTC 30984   Fasciola hepatica   Tilletia caries   environmental samples   Ensifer adhaerens   Bothrops jararaca   Pyricularia oryzae P131   Canis lupus familiaris   Bordetella pertussis Tohama I   Nicotiana africana   Leishmania donovani Ld 2001   West Nile virus   Pachycladon cheesemanii   Xanthomonas citri pv. glycines str. 8ra   Streptomyces sp. MC1   Pseudomonas sp. UK4   Venturia inaequalis   Tilletia controversa   Delftia acidovorans SPH-1   Plasmodium yoelii yoelii   Xanthomonas campestris pv. vesicatoria str. 85-10   Pomacea maculata   Entamoeba histolytica HM-1:IMSS-A   Mycobacterium tuberculosis H37Rv   Podospora   Bacillus subtilis subsp. subtilis   metagenomes   Candidatus Carsonella ruddii DC   Staphylococcus haemolyticus   unclassified Thermococcus   Scolopendra morsitans   Eremothecium gossypii   Bison   Stylosanthes guianensis   Cryptococcus neoformans var. grubii H99W   Acromyrmex echinatior   freshwater sediment metagenome   Colpophyllia natans   Lentimonas   Candidatus Thioglobus autotrophicus   Thermochaetoides thermophila   Staphylococcus lugdunensis N920143   Onchocerca volvulus   Aquilaria sinensis   Mycobacterium avium subsp. paratuberculosis   Aspergillus niger   Paracoccus denitrificans   Chlorobaculum tepidum   Vibrio cholerae O1 biovar El Tor str. N16961   Cicer arietinum   Fusarium oxysporum f. sp. lycopersici 4287   Doryteuthis pealeii   Xanthomonas oryzae pv. oryzae PXO99A   Brachyspiraceae   Ricinus communis   Macaca fascicularis   Legionella pneumophila subsp. pneumophila   Aspergillus nidulans   Actinomycetia   Proteus mirabilis HI4320   Didelphis aurita   Methylocystis sp. SC2   Nostoc sp.   Gynandropsis gynandra   Streptococcus equi subsp. equi 4047   Teleogryllus oceanicus   Nicotiana x sanderae   Sarcophilus harrisii   Pandanus amaryllifolius   Oreochromis niloticus niloticus   Prototheca zopfii   Bacteroides fragilis 638R   Saccharum hybrid cultivar SP80-3280   Rhizobium sp. Leaf68   Nicotiana tabacum   Aiptasia   Oryza sativa Japonica Group   Pinctada maxima   Equus hydruntinus   Willaertia magna   Mycobacterium tuberculosis variant bovis BCG   Allochromatium vinosum DSM 180   Leuconostoc gelidum subsp. gasicomitatum   Vitis riparia x Vitis rupestris   Phormidium sp. OSCR   Capra pyrenaica   Naegleria gruberi   Lichtheimia corymbifera JMRC:FSU:9682   Butyrivibrio fibrisolvens   Renibacterium salmoninarum ATCC 33209   Porphyromonas gingivalis   Plasmodium falciparum 58.1   Drosophila   Tetratrichomonas gallinarum   Citrus wilsonii   Methanospirillum stamsii   Wolbachia endosymbiont of Onchocerca volvulus str. Cameroon   Schistosoma japonicum   Bacillus cytotoxicus NVH 391-98   Vibrio parahaemolyticus   Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130   Yersinia pseudotuberculosis   Desulfofundulus kuznetsovii DSM 6115   Bos taurus   Acinetobacter baumannii 1656-2   Saturnispora dispora   Nicotiana forgetiana   Mycobacterium marinum ATCC BAA-535   Fabomonas tropica   Neoporphyra haitanensis   Vertebrata   Arabidopsis   mouse gut metagenome   Plasmodium sp. pBT9   Vitis riparia   Nothobranchius furzeri   Gefionella okellyi   glacier metagenome   Selenomonas sputigena ATCC 35185   Pachycladon fastigiatum   Neptuniibacter caesariensis   Octopodiformes   Staphylococcus cohnii   Leishmania major strain Friedlin   Thymallus thymallus   Mrakia psychrophila   Pteropus alecto   Bacillus amyloliquefaciens DSM 7 = ATCC 23350   Bacillus licheniformis   Penicillium verrucosum   Stichodactyla haddoni   Pongo sp.   Andrias davidianus   Dictyostelium discoideum   Cyprinus carpio   Phytophthora sojae   Mycobacterium tuberculosis H37Rv_2009   Acanthoscurria gomesiana   Leuconostoc gelidum subsp. gelidum   Escherichia coli str. K-12 substr. W3110   Myxobilatus gasterostei   Gallus gallus   Prochlorococcus marinus subsp. marinus str. CCMP1375   Trypanosoma brucei   Leishmania chagasi   Bombus terrestris audax   Bacillus thuringiensis serovar berliner ATCC 10792   Sulfolobus islandicus LAL14/1   Oomycota   Beta vulgaris subsp. vulgaris   Cucumis sativus   Enterococcus mundtii CRL35   Yersinia pestis CO92   Streptococcus pyogenes MGAS5005   Stephanorhinus   Parasteatoda tepidariorum   Fusarium oxysporum Fo47   Agrobacterium fabrum str. C58   Agkistrodon contortrix   Naja ashei   Stylophora pistillata   Arachis hypogaea var. vulgaris   Macaca mulatta   Triticum aestivum   Obba rivulosa   Vitis vinifera   Ehrlichia ruminantium str. Gardel   Aspergillus niger ATCC 13496   Mylodon darwinii   Mycoplasma pneumoniae M29   Mycoplasma hominis ATCC 23114   Olavius algarvensis Gamma 3 endosymbiont   human metagenome   Dictyostelium discoideum AX4   Glycine max   Escherichia coli Nissle 1917   Pseudomonas aeruginosa str. E2UoS   Microbacterium sp.   Conus caracteristicus   Nanger dama mhorr   Aspergillus terreus NIH2624   Triticum turgidum subsp. durum   Tenebrio molitor   Eutrema salsugineum   Bacteria   Sulfolobus islandicus   Human papillomavirus type 16   Staphylococcus pseudintermedius   Methylorubrum extorquens PA1   Clostridium saccharoperbutylacetonicum   'Phaseolus vulgaris' phytoplasma   Akkermansia muciniphila ATCC BAA-835   Staphylococcus aureus subsp. aureus USA300   Clostridioides difficile 050-P50-2011   Synechococcus cyanophage syn   Vibrio cholerae   Thermoplasma acidophilum DSM 1728   Beta vulgaris   Persicaria minor   Potentilla saundersiana   Castor canadensis   Shigella flexneri   Halomonas sp. HL-48   Diaphorina citri   Cladocopium goreaui   Citrus hybrid cultivar   Calvadosia cruxmelitensis   Rhodotorula toruloides   Tortispora caseinolytica   Kluyveromyces lactis NRRL Y-1140   Salmonella enterica subsp. enterica serovar Typhi str. CT18   Coxsackievirus B3   Leishmania infantum JPCM5   Rathayibacter toxicus  

TISSUE(S): Liver

SUBMITTER: Meital Kupervaser  

LAB HEAD: Anthony H. Futerman

PROVIDER: PXD031088 | Pride | 2022-04-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuant_1.6.0.16.zip Other
QEP2_6604_TFU_05D_null1_270618.raw Raw
QEP2_6604_TFU_05D_null2_270618.raw Raw
QEP2_6604_TFU_05D_null3_270618.raw Raw
QEP2_6604_TFU_05D_wt1_270618.raw Raw
Items per page:
1 - 5 of 25
altmetric image

Publications

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis.

Kim Jiyoon L JL   Mestre Beatriz B   Malitsky Sergey S   Itkin Maxim M   Kupervaser Meital M   Futerman Anthony H AH  

The Journal of biological chemistry 20220216 4


Dihydroceramide is a lipid molecule generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, namely sphinganine and fatty acyl-CoAs. Sphinganine is generated via the sequential activity of two integral membrane proteins located in the endoplasmic reticulum. Less is known about the source of the fatty acyl-CoAs, although a number of cytosolic proteins in the pathways of acyl-CoA generation modulate ceramide synthesis via direct or indirect interaction with the Ce  ...[more]

Similar Datasets

2005-01-01 | S-EPMC549621 | BioStudies
2017-01-01 | S-EPMC5472424 | BioStudies
2022-01-17 | PXD029496 | Pride
2012-01-01 | S-EPMC3551351 | BioStudies
2018-01-01 | S-EPMC6016465 | BioStudies
2016-01-01 | S-EPMC4889366 | BioStudies
1000-01-01 | S-EPMC2856296 | BioStudies
2013-01-01 | S-EPMC3843679 | BioStudies
1000-01-01 | S-EPMC3111271 | BioStudies
2002-01-01 | S-EPMC2995503 | BioStudies