Interactome of DENV2 NS1 and NS5 in Aedes albopictus mosquito cells

ABSTRACT: Efficient virus replication in its vector, Aedes mosquitoes, is essential for the transmission of arboviral diseases like dengue virus (DENV) in populations. In order to identify RNA-independent host factors involved in DENV replication in mosquitoes, we established a system expressing all non-structural proteins within the context of the macro protein complex as observed during viral infections. Mosquito host factors interacting with 3xFLAGED-tagged DENV non-structural proteins NS1 or NS5 proteins were identified by label-free mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Aedes Albopictus C6/36 Cell Densovirus

TISSUE(S): Cell Culture

DISEASE(S): Dengue Disease

SUBMITTER: Pascal Jansen  

LAB HEAD: Ronald Pieter van Rij

PROVIDER: PXD031112 | Pride | 2022-08-25

REPOSITORIES: Pride