Dataset Information

Palmitoylation proteins in extracellular vesicles

ABSTRACT: The aim of this project is to identify and quantify palmitoylated proteins present in the extracellular vesicles among four experimental groups. Four experimental groups are WT+SHAM, WT+CLP, DEP+SHAM, and DEP+CLP.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Sherry Yang

LAB HEAD: Sarah Yuan

PROVIDER: PXD031118 | Pride | 2025-08-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	mz_191223_SY590_DepCLP_2_30pct.raw	Raw
	mz_191223_SY590_DepCLP_3_30pct.raw	Raw
	mz_191223_SY590_DepSham_1_30pct.raw	Raw
	mz_191223_SY590_DepSham_2_30pct.raw	Raw
	mz_191223_SY590_DepSham_3_30pct.raw	Raw

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Publications

Correction to <i>Journal of Extracellular Biology</i> Articles.

Journal of extracellular biology 20250724 7

[This corrects the article DOI: 10.1002/jex2.70051.]. ...[more]

PMID: 40718630

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Project description:Dysregulated cardiac function after sepsis is common in intensive care unit (ICU) and known to predict poor long-term outcome and increase mortality. Effective therapeutic strategies are largely lacking. Moreover, the pathological feature and the molecular mechanism underlying cardiac dysfunction induced by sepsis remain unclear. Here, by performing echocardiograms on rodents after induction of polymicrobial sepsis with cecum ligation and puncture (CLP), we assessed the temporal dynamics of left ventricular ejection fraction (LVEF) and a serial of hemodynamics parameters on animals at different time point after CLP. Intriguingly, the mean LVEF is comparable in mice induced by CLP and sham, whereas survivors post CLP had stable LVEF and non-survivors had markedly fluctuated LVEF at early phase of CLP induction, suggesting LVEF away from normal range is highly associated with mortality. Consistent with clinical observations of depressed, preserved or hyperdynamic LVEF in septic patients from data compiled using our ICU cohort and from other studies, CLP-induced mice fall into three groups based on LVEF measured at 24 hours after surgery: high LVEF (HEF, LVEF>=90%), low LVEF (LEF, LVEF<65%), and normal LVEF (NEF, 65%=<LVEF<90%). We performed genome-wide transcriptomic and proteomic profiling on left ventricle samples collected from three CLP groups and sham mice. By implementing pathway analysis, gene set enrichment and coexpression network analysis, we identified jointly and distinctively changed genes, proteins and biologically-essential processes and pathways in three CLP groups with different LVEF. Notably, transmission electron microscopy examination shows remarkable mitochondrial and sarcomere defects in three CLP groups with different phenotypes associated with LVEF variances. Together, this study systematically characterizes the molecular, morphological, and functional alterations in CLP-induced cardiac injury, serving as a framework for future research into pathology and molecular mechanism of sepsis-induced cardiomyopathy.

Dataset Information

Palmitoylation proteins in extracellular vesicles

Dataset's files

Publications

Correction to <i>Journal of Extracellular Biology</i> Articles.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Palmitoylation proteins in extracellular vesicles

Dataset's files

Publications

Correction to &lt;i&gt;Journal of Extracellular Biology&lt;/i&gt; Articles.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Correction to <i>Journal of Extracellular Biology</i> Articles.