Dataset Information
Modulation of the tumor promoting functions of cancer associated fibroblasts by PDE5 inhibition
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Antigoni Manousopoulou
LAB HEAD: Spiros D. Garbis
PROVIDER: PXD031148 | Pride | 2022-08-12
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 11may15_vardenefil_1.raw | Raw | |||
| 11may15_vardenefil_10.raw | Raw | |||
| 11may15_vardenefil_2.raw | Raw | |||
| 11may15_vardenefil_21.raw | Raw | |||
| 11may15_vardenefil_22.raw | Raw |
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Publications
Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.
Cell reports. Medicine 20220601 6
The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type, cancer-associated fibroblasts (CAFs) with phosphodiesterase type 5 inhibitors (PDE5i), we can enhance the efficacy of standard-of-care chemotherapy. In ex vivo conditions, PDE5i prevent the transdifferentiation of normal fibroblasts to CAF and aboli ...[more]
