Aging-Associated Changes in CSF Protein Abundances and Structures Revealed by a Modified LiP-MS Screen

ABSTRACT: We performed LiP-MS on CSF from young and old mice with a modified analysis pipeline. We found 38 protein groups that change in abundance with aging, most dominantly immunoglobulins of the IgM subclass. We discovered six high-confidence candidates that appeared to change in structure with aging.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Steven Shuken  

LAB HEAD: Tony Wyss-Coray

PROVIDER: PXD031174 | Pride | 2022-08-22

REPOSITORIES: Pride